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Depot delivery of dexamethasone and cediranib for the treatment of brain tumor associated edema in an intracranial rat glioma model

Ong, Qunya ; Hochberg, Fred H ; Cima, Michael J

Journal of Controlled Release, 10 November 2015, Vol.217, pp.183-190 [Periódico revisado por pares]

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  • Título:
    Depot delivery of dexamethasone and cediranib for the treatment of brain tumor associated edema in an intracranial rat glioma model
  • Autor: Ong, Qunya ; Hochberg, Fred H ; Cima, Michael J
  • Assuntos: Drug Delivery ; Depot ; Dexamethasone ; Cediranib ; Brain Tumor Associated Edema ; Drug Delivery ; Depot ; Dexamethasone ; Cediranib ; Brain Tumor Associated Edema ; Pharmacy, Therapeutics, & Pharmacology
  • É parte de: Journal of Controlled Release, 10 November 2015, Vol.217, pp.183-190
  • Descrição: Treatments of brain tumor associated edema with systemically delivered dexamethasone, the standard of care, and cediranib, a novel anti-edema agent, are associated with systemic toxicities in brain tumor patients. A tunable, reservoir-based drug delivery device was developed to investigate the effects of delivering dexamethasone and cediranib locally in the brain in an intracranial 9L gliosarcoma rat model. Reproducible, sustained releases of both dexamethasone and solid dispersion of cediranib in polyvinylpyrrolidone (AZD/PVP) from these devices were achieved. The water-soluble AZD/PVP, which exhibited similar bioactivity as cediranib, was developed to enhance the release of cediranib from the device. Local and systemic administration of both dexamethasone and cediranib was equally efficacious in alleviating edema but had no effect on tumor growth. Edema reduction led to modest but significant improvement in survival. Local delivery of dexamethasone prevented dexamethasone-induced...
  • Idioma: Inglês

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