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Synthesis, characterization and comparative evaluation of phenoxy ring containing long chain gemini imidazolium and pyridinium amphiphiles

Bhadani, Avinash ; Kataria, Hardeep ; Singh, Sukhprit

Journal of Colloid And Interface Science, 01 September 2011, Vol.361(1), pp.33-41 [Periódico revisado por pares]

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  • Título:
    Synthesis, characterization and comparative evaluation of phenoxy ring containing long chain gemini imidazolium and pyridinium amphiphiles
  • Autor: Bhadani, Avinash ; Kataria, Hardeep ; Singh, Sukhprit
  • Assuntos: Gemini Imidazolium Amphiphile ; Gemini Pyridinium Amphiphile ; Cmc ; DNA Interaction ; Cytotoxicity ; Engineering ; Chemistry
  • É parte de: Journal of Colloid And Interface Science, 01 September 2011, Vol.361(1), pp.33-41
  • Descrição: Phenoxy ring containing long chain gemini imidazolium amphiphite synthesized from renewable cardanol oil and its interaction with pDNA to form lipoplexes. . ► Eight gemini imidazolium and pyridinium amphiphiles have been synthesized. ► Phenoxy ring containing long chain gemini amphiphiles have lower cmc values compared to other cationic gemini surfactants. ► Gemini amphiphiles demonstrate high DNA binding affinity. ► Amphiphiles form stable lipoplex with DNA. ► Display low cytotoxicity on C6 Glioma cell. Two series of phenoxy ring containing long chain imidazolium and pyridinium based gemini amphiphiles have been synthesized from renewable cardanol oil having different spacers (i. e. S (CH ) S , where is 2, 3, 4 & 6). Critical micelle concentration (cmc) of these new gemini amphiphiles has been determined by conductivity method. Further, these new cationic amphiphiles have been evaluated for their DNA binding capability by agarose gel electrophoresis, ethidium bromide exclusion experiments and transmission electron microscopy (TEM). The cytotoxicity of these new amphiphiles have been evaluated by MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Comparative studies of these phenoxy ring containing long chain gemini imidazolium amphiphiles and their pyridinium analogues depicted low cmc values of the later but greater DNA interaction capability and low cytotoxicity of the former series of amphiphiles.
  • Idioma: Inglês

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