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A coupled framework of in situ and in silico analysis reveals the role of lateral force transmission in force production in volumetric muscle loss injuries

Westman, Amanda M ; Dyer, Sarah E ; Remer, J. David ; Hu, Xiao ; Christ, George J ; Blemker, Silvia S

Journal of Biomechanics, 06 March 2019, Vol.85, pp.118-125 [Periódico revisado por pares]

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  • Título:
    A coupled framework of in situ and in silico analysis reveals the role of lateral force transmission in force production in volumetric muscle loss injuries
  • Autor: Westman, Amanda M ; Dyer, Sarah E ; Remer, J. David ; Hu, Xiao ; Christ, George J ; Blemker, Silvia S
  • Assuntos: Finite-Element Modeling ; Tissue Engineering ; Volumetric Muscle Loss ; Muscle Mechanics ; Lateral Force Transmission ; Medicine ; Engineering ; Anatomy & Physiology
  • É parte de: Journal of Biomechanics, 06 March 2019, Vol.85, pp.118-125
  • Descrição: Volumetric muscle loss injuries (VML) are challenging to treat because of the variability in wound location. Regenerative medicine offers promising alternative treatments, but there is little understanding of the correlation between magnitude of VML injuries and corresponding functional deficits that must be addressed. There is a need for a tool that can elucidate the relationship between VML injury and force loss, as well as the impact on specific mechanisms responsible for force production. The purpose of this study was to develop a novel coupled framework of and methods to more precisely understand the relationship between injury location and force production deficits. We created a three-dimensional finite-element model of the pennate latissimus dorsi (LD) muscle in the rat and validated the model experimentally. We found that the model’s prediction (2.6 N/g Model I, 2.1 N/g Model V) compared favorably to testing...
  • Idioma: Inglês

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