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Diesel exhaust particle induction of IL-17A contributes to severe asthma

Brandt, Eric B ; Kovacic, Melinda Butsch ; Lee, Gerald B ; Gibson, Aaron M ; Acciani, Thomas H ; Le Cras, Timothy D ; Ryan, Patrick H ; Budelsky, Alison L ; Khurana Hershey, Gurjit K

The Journal of Allergy and Clinical Immunology, November 2013, Vol.132(5), pp.1194-1204.e2 [Periódico revisado por pares]

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  • Título:
    Diesel exhaust particle induction of IL-17A contributes to severe asthma
  • Autor: Brandt, Eric B ; Kovacic, Melinda Butsch ; Lee, Gerald B ; Gibson, Aaron M ; Acciani, Thomas H ; Le Cras, Timothy D ; Ryan, Patrick H ; Budelsky, Alison L ; Khurana Hershey, Gurjit K
  • Assuntos: Allergic Asthma ; House Dust Mite ; Diesel Exhaust Particle ; Il-17a ; Regulatory T Cell ; Medicine
  • É parte de: The Journal of Allergy and Clinical Immunology, November 2013, Vol.132(5), pp.1194-1204.e2
  • Descrição: IL-17A has been implicated in severe forms of asthma. However, the factors that promote IL-17A production during the pathogenesis of severe asthma remain undefined. Diesel exhaust particles (DEPs) are a major component of traffic-related air pollution and are implicated in asthma pathogenesis and exacerbation. We sought to determine the mechanism by which DEP exposure affects asthma severity using human and mouse studies. BALB/c mice were challenged with DEPs with or without house dust mite (HDM) extract. Airway inflammation and function, bronchoalveolar lavage fluid cytokine levels, and flow cytometry of lung T cells were assessed. The effect of DEP exposure on the frequency of asthma symptoms and serum cytokine levels was determined in children with allergic asthma. In mice exposure to DEPs alone did not induce asthma. DEP and HDM coexposure markedly enhanced airway hyperresponsiveness compared with HDM exposure alone...
  • Idioma: Inglês

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