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Practical Method of Adaptive Radiotherapy for Prostate Cancer Using Real-Time Electromagnetic Tracking

Olsen, Jeffrey R ; Noel, Camille E ; Baker, Kenneth ; Santanam, Lakshmi ; Michalski, Jeff M ; Parikh, Parag J

International Journal of Radiation Oncology, Biology, Physics, 01 April 2012, Vol.82(5), pp.1903-1911 [Periódico revisado por pares]

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  • Título:
    Practical Method of Adaptive Radiotherapy for Prostate Cancer Using Real-Time Electromagnetic Tracking
  • Autor: Olsen, Jeffrey R ; Noel, Camille E ; Baker, Kenneth ; Santanam, Lakshmi ; Michalski, Jeff M ; Parikh, Parag J
  • Assuntos: Prostate ; Cancer ; Radiotherapy ; Intrafraction ; Adaptive ; Prostate ; Cancer ; Radiotherapy ; Intrafraction ; Adaptive ; Medicine
  • É parte de: International Journal of Radiation Oncology, Biology, Physics, 01 April 2012, Vol.82(5), pp.1903-1911
  • Descrição: We have created an automated process using real-time tracking data to evaluate the adequacy of planning target volume (PTV) margins in prostate cancer, allowing a process of adaptive radiotherapy with minimal physician workload. We present an analysis of PTV adequacy and a proposed adaptive process. Tracking data were analyzed for 15 patients who underwent step-and-shoot multi-leaf collimation (SMLC) intensity-modulated radiation therapy (IMRT) with uniform 5-mm PTV margins for prostate cancer using the Calypso® Localization System. Additional plans were generated with 0- and 3-mm margins. A custom software application using the planned dose distribution and structure location from computed tomography (CT) simulation was developed to evaluate the dosimetric impact to the target due to motion. The dose delivered to the prostate was calculated for the initial three, five, and 10 fractions, and for the entire treatment. Treatment was accepted as adequate if the...
  • Idioma: Inglês

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