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Cigarette smoking is associated with cortical thinning in anterior frontal regions, insula and regions showing atrophy in early Alzheimer’s Disease

Durazzo, Timothy C ; Meyerhoff, Dieter J ; Yoder, Karmen K

Drug and Alcohol Dependence, 01 November 2018, Vol.192, pp.277-284 [Periódico revisado por pares]

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  • Título:
    Cigarette smoking is associated with cortical thinning in anterior frontal regions, insula and regions showing atrophy in early Alzheimer’s Disease
  • Autor: Durazzo, Timothy C ; Meyerhoff, Dieter J ; Yoder, Karmen K
  • Assuntos: Cigarette Smoking ; Magnetic Resonance Imaging ; Cortical Thickness ; Decision-Making ; Impulsivity ; Freesurfer ; Cigarette Smoking ; Magnetic Resonance Imaging ; Cortical Thickness ; Decision-Making ; Impulsivity ; Freesurfer ; Social Welfare & Social Work
  • É parte de: Drug and Alcohol Dependence, 01 November 2018, Vol.192, pp.277-284
  • Descrição: •Smokers showed cortical thinning in multiple brain regions compared to non-smokers.•Greater cigarette pack years was related to thinner cortex in multiple regions.•In Smokers, impulsivity and poorer decision-making were related to thinner cortex. Magnetic resonance imaging studies of cigarette smoking-related effects on human brain structure primarily focused on cortical volumes. Much less is known about the effects of smoking on cortical thickness. Smokers and Non-smokers were compared on regional cortical thickness. We predicted smokers would demonstrate greater age-related thinning localized to anterior frontal regions that serve as nodes for the executive, salience, and emotional regulation networks (ESER regions) and those demonstrating significant atrophy in early Alzheimer’s Disease (AD regions). Non-smokers (n = 41) and smokers (n = 41), 22–70 years of age, completed a 4 T MRI study. Regional cortical thickness was quantitated via...
  • Idioma: Inglês

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