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Interactive effects of chronic cigarette smoking and age on hippocampal volumes

Durazzo, Timothy C ; Meyerhoff, Dieter J ; Nixon, Sara Jo

Drug and Alcohol Dependence, 01 December 2013, Vol.133(2), pp.704-711 [Periódico revisado por pares]

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  • Título:
    Interactive effects of chronic cigarette smoking and age on hippocampal volumes
  • Autor: Durazzo, Timothy C ; Meyerhoff, Dieter J ; Nixon, Sara Jo
  • Assuntos: Cigarette Smoking ; Mri ; Hippocampus ; Hippocampal Subfields ; Learning and Memory ; Aging ; Cigarette Smoking ; Mri ; Hippocampus ; Hippocampal Subfields ; Learning and Memory ; Aging ; Social Welfare & Social Work
  • É parte de: Drug and Alcohol Dependence, 01 December 2013, Vol.133(2), pp.704-711
  • Descrição: Previous cross-sectional MRI studies with healthy, young-to-middle-aged adults reported no significant differences between smokers and non-smokers on total hippocampal volume. However, these studies did not specifically test for greater age-related volume loss in the total hippocampus or hippocampal subregions in smokers, and did they did not examine relationships between hippocampal and subfield volumes and episodic learning and memory performance. Healthy, young-to-middle-aged (45±12 years of age) smokers (n=39) and non-smokers (n=43) were compared on total hippocampal and subfield volumes derived from high-resolution 4Tesla MRI, emphasizing testing for greater age-related volume losses in smokers. Associations between hippocampal volumes and measures of episodic learning and memory were examined. Smokers showed significantly smaller volumes, as well as greater volume loss with increasing age than non-smokers in the bilateral total hippocampus...
  • Idioma: Inglês

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