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Comparative study of spontaneous deamination of adenine and cytosine in unbuffered aqueous solution at room temperature

Wang, Shiliang ; Hu, Anguang

Chemical Physics Letters, 01 June 2016, Vol.653, pp.207-211 [Periódico revisado por pares]

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  • Título:
    Comparative study of spontaneous deamination of adenine and cytosine in unbuffered aqueous solution at room temperature
  • Autor: Wang, Shiliang ; Hu, Anguang
  • Assuntos: Chemistry
  • É parte de: Chemical Physics Letters, 01 June 2016, Vol.653, pp.207-211
  • Descrição: Adenine in unbuffered nanopure water at a concentration of 2 mM is completely deaminated (>99%) to hypoxanthine at room temperature in ca. 10 weeks, with an estimated half-life ( ) less than 10 days, about six orders of magnitude faster than previously reported. Cytosine is not deaminated under the same condition, even after 3 years. This is in contrast to previous observations that cytosine deaminates 20–40 times faster than adenine free base, in nucleoside, in nucleotide and in single-stranded DNA in buffered neutral aqueous solutions.
  • Idioma: Inglês

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