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Usefulness of Isosorbide Dinitrate and Hydralazine as Add-on Therapy in Patients Discharged for Advanced Decompensated Heart Failure

Mullens, Wilfried ; Abrahams, Zuheir ; Francis, Gary S ; Sokos, George ; Starling, Randall C ; Young, James B ; Taylor, David O ; Tang, W.H. Wilson

The American Journal of Cardiology, 2009, Vol.103(8), pp.1113-1119 [Periódico revisado por pares]

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  • Título:
    Usefulness of Isosorbide Dinitrate and Hydralazine as Add-on Therapy in Patients Discharged for Advanced Decompensated Heart Failure
  • Autor: Mullens, Wilfried ; Abrahams, Zuheir ; Francis, Gary S ; Sokos, George ; Starling, Randall C ; Young, James B ; Taylor, David O ; Tang, W.H. Wilson
  • Assuntos: Medicine
  • É parte de: The American Journal of Cardiology, 2009, Vol.103(8), pp.1113-1119
  • Descrição: Data supporting the use of oral isosorbide dinitrate and/or hydralazine (I/H) as add-on therapy to standard neurohormonal antagonists in advanced decompensated heart failure (ADHF) are limited, especially in the non–African-American population. Our objective was to determine if addition of I/H to standard neurohormonal blockade in patients discharged from the hospital with ADHF is associated with improved hemodynamic profiles and improved clinical outcomes. We reviewed consecutive patients with ADHF admitted from 2003 to 2006 with a cardiac index ≤2.2 L/min/m admitted for intensive medical therapy. Patients discharged with angiotensin-converting enzyme inhibitors and/or angiotensin receptor blockers (control group) were compared with those receiving angiotensin-converting enzyme inhibitors/angiotensin receptor blockers plus I/H (I/H group). The control (n = 97) and I/H (n = 142) groups had similar demographic characteristics, baseline blood pressure, and...
  • Idioma: Inglês

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