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The impact of left ventricular size on response to cardiac resynchronization therapy

Rickard, John ; Brennan, Danielle M ; Martin, David O ; Hsich, Eileen ; Tang, W.H. Wilson ; Lindsay, Bruce D ; Starling, Randall C ; Wilkoff, Bruce L ; Grimm, Richard A

American Heart Journal, 2011, Vol.162(4), pp.646-653 [Periódico revisado por pares]

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  • Título:
    The impact of left ventricular size on response to cardiac resynchronization therapy
  • Autor: Rickard, John ; Brennan, Danielle M ; Martin, David O ; Hsich, Eileen ; Tang, W.H. Wilson ; Lindsay, Bruce D ; Starling, Randall C ; Wilkoff, Bruce L ; Grimm, Richard A
  • Assuntos: Medicine
  • É parte de: American Heart Journal, 2011, Vol.162(4), pp.646-653
  • Descrição: Patients with nondilated (NDCM) or severely dilated cardiomyopathies (SDCM) have been underrepresented in clinical trials of cardiac resynchronization therapy (CRT). We examined changes in left ventricular ejection fraction (LVEF) and survival in patients with NDCM or SDCM compared with those with traditionally studied moderately dilated cardiomyopathy. We evaluated 800 consecutive patients undergoing the original implantation of a biventricular pacemaker between January 2004 and August 2007. For inclusion, patients had a baseline and pre-CRT echocardiogram, an LVEF ≤40%, a US social security number, and New York Heart Association class II to IV symptoms on standard medical therapy. Patients with a follow-up echocardiogram 2 months after device implantation were included in an analysis of remodeling. Using multivariate models, the impact of baseline left ventricular end-diastolic diameter (LVEDD) on change in LVEF and all-cause mortality was assessed....
  • Idioma: Inglês

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