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Adjuvant radiation therapy for rectal carcinoma: Predictors of outcome

Myerson, Robert J ; Michalski, Jeff M ; King, Maurice L ; Birnbaum, Elisa ; Fleshman, James ; Fry, Robert ; Kodner, Ira ; Lacey, David ; Lockett, Mary Ann

International Journal of Radiation Oncology, Biology, Physics, 1995, Vol.32(1), pp.41-50 [Periódico revisado por pares]

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  • Título:
    Adjuvant radiation therapy for rectal carcinoma: Predictors of outcome
  • Autor: Myerson, Robert J ; Michalski, Jeff M ; King, Maurice L ; Birnbaum, Elisa ; Fleshman, James ; Fry, Robert ; Kodner, Ira ; Lacey, David ; Lockett, Mary Ann
  • Assuntos: Rectal Carcinoma ; Radiation Therapy ; Rectal Carcinoma ; Radiation Therapy ; Medicine
  • É parte de: International Journal of Radiation Oncology, Biology, Physics, 1995, Vol.32(1), pp.41-50
  • Descrição: Purpose : To review predictors of outcome, including sequencing of modalities and pretreatment findings for adjuvantly treated rectal cancer. Methods and Materials : From 1975 through 1990, 307 patients with adenocarcinoma of the rectum underwent adjuvant radiation therapy. In 251 cases the radiation therapy was administered preoperatively, either 40–50 Gy (median dose 45 Gy) followed in 6–7 weeks by surgery (210 cases), or 20 Gy in five fractions immediately prior to surgery (41 cases). In 56 cases, patients were referred postoperatively for radiation (median dose 50 Gy). Adjuvant chemotherapy was never given concurrently with the preoperative radiation (RT), although 43 of the cases (including 14 of the preoperative RT cases) received postoperative chemotherapy. Results : Multivariate analysis (Cox model) indicated that significant predictors of better overall freedom from...
  • Idioma: Inglês

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