skip to main content

The effects of oral ibopamine in patients with mild heart failure — a double blind placebo controlled comparison to furosemide

Parker, John O

International Journal of Cardiology, 1993, Vol.40(3), pp.221-227 [Periódico revisado por pares]

Texto completo disponível

Citações Citado por
  • Título:
    The effects of oral ibopamine in patients with mild heart failure — a double blind placebo controlled comparison to furosemide
  • Autor: Parker, John O
  • Assuntos: Heart Failure ; Inotropes ; Vasodilators ; Medicine
  • É parte de: International Journal of Cardiology, 1993, Vol.40(3), pp.221-227
  • Descrição: The effect of ibopamine and furosemide in 130 patients with NYHA Class I and II heart failure were studied in a parallel, double-blind, randomized placebo-controlled multi-centre trial. Ibopamine 200 mg b.i.d. was compared to furosemide 40 mg q.d. and placebo. A 1- to 2-week single-blind run-in period was followed by an 8-week double-blind treatment period. Reproducible treadmill exercise test times with the modified Naughton-Balke protocol were required for randomization. Exercise times increased significantly in comparison to the placebo group after 8 weeks of therapy for both the furosemide group (1.2 min, P < 0.035) and the ibopamine group (1.3 min, P < 0.025). Neither furosemide nor ibopamine affected quality of life assessments. Adverse clinical experiences were generally mild and similar in frequency amongst the three treatment groups. The results of this study show the usefulness of both ibopamine and furosemide as monotherapy in patients with mild congestive heart failure.
  • Idioma: Inglês

Buscando em bases de dados remotas. Favor aguardar.