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The polymorphisms of genes associated with the profile of fatty acids of sheep

C. Esteves ; K.G. Livramento ; L.V. Paiva ; A.P. Peconick ; I.F.F. Garcia ; C.A.P. Garbossa ; P.B. Faria

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, Vol.71(1), pp.303-313 [Periódico revisado por pares]

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  • Título:
    The polymorphisms of genes associated with the profile of fatty acids of sheep
  • Autor: C. Esteves ; K.G. Livramento ; L.V. Paiva ; A.P. Peconick ; I.F.F. Garcia ; C.A.P. Garbossa ; P.B. Faria
  • Assuntos: Diacilglicerol Aciltransferase ; Ácido Graxo Sintase ; Estearoil-Coa Dessaturase ; Veterinary Medicine
  • É parte de: Arquivo Brasileiro de Medicina Veterinária e Zootecnia, Vol.71(1), pp.303-313
  • Descrição: ABSTRACT The present study aimed to evaluate the occurrence of polymorphisms in Diacylglycerol acyltransferase (DGTA-1 and 2), Fatty acid synthase (FASN), Stearoyl-CoA desaturase (SCD) genes and the Thioesterase domain of FASN (TE-FASN) gene that may be related to the lipid profile. In the experiment, a total of 84 sheep from different genetic groups were used. For the evaluation of the polymorphism of the genes, PCR-Single Strand Conformation Polymorphism (SSCP) technique and subsequent sequencing were used. In DGAT-2 gene, four genotypes were identified with the presence of 6 polymorphisms, with two (c.229T> C; c.255T> C) that resulted into the exchange of phenylalanine by leucine. In FASN gene, two genotypes were identified. In TE-FASN gene, three genotypes and 17 polymorphisms were identified. DGAT-1 and SCD genes did not reveal the occurrence of polymorphism. There was difference in relation to C14: 0, C18: 0 fatty acids and Δ9-desaturase C18 for DGAT-2 gene and of C18: 2ω6t for TE-FASN. There were differences among the genetic groups for C10: 0, C12: 0, C17: 0, C18: 2ω6t, C18: 3ω3, C20: 2, total of ω3, ω3/ω6 and atherogenicity index. There is occurrence of polymorphism of DGAT-2 and TE-FASN genes and these should be further studied in sheep since they revealed influence of the genotypes on the fatty acid profile.
  • Idioma: Inglês

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