skip to main content

Histocompatible Embryonic Stem Cells by Parthenogenesis

Kim, K. ; Lerou, P. ; Yabuuchi, A. ; Lengerke, C. ; Ng, K. ; West, J. ; Kirby, A. ; Daly, M. J. ; Daley, G. Q.

Science, 01/26/2007, Vol.315(5811), pp.482-486 [Periódico revisado por pares]

Texto completo disponível

Ver todas as versões
Citações Citado por
  • Título:
    Histocompatible Embryonic Stem Cells by Parthenogenesis
  • Autor: Kim, K. ; Lerou, P. ; Yabuuchi, A. ; Lengerke, C. ; Ng, K. ; West, J. ; Kirby, A. ; Daly, M. J. ; Daley, G. Q.
  • Assuntos: Stem Cells ; Transplants & Implants ; Rodents ; Tissue ; Embryos
  • É parte de: Science, 01/26/2007, Vol.315(5811), pp.482-486
  • Descrição: Genetically matched pluripotent embryonic stem (ES) cells generated via nuclear transfer or parthenogenesis (pES cells) are a potential source of histocompatible cells and tissues for transplantation. After parthenogenetic activation of murine oocytes and interruption of meiosis I or II, we isolated and genotyped pES cells and characterized those that carried the full complement of major histocompatibility complex (MHC) antigens of the oocyte donor. Differentiated tissues from these pES cells engrafted in immunocompetent MHC-matched mouse recipients, demonstrating that selected pES cells can serve as a source of histocompatible tissues for transplantation. [PUBLICATION ]
  • Idioma: Inglês

Buscando em bases de dados remotas. Favor aguardar.