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Synthesis of the Azetidinyl-Thiazoline Fragment of Vioprolides A and C

Chopin, Nathalie ; Couty, Francois ; Evano, Gwilherm

Letters in Organic Chemistry, 2010, Vol.7(5), p.353-359 [Periódico revisado por pares]

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  • Título:
    Synthesis of the Azetidinyl-Thiazoline Fragment of Vioprolides A and C
  • Autor: Chopin, Nathalie ; Couty, Francois ; Evano, Gwilherm
  • Assuntos: Azetidines ; Natural Products ; Antifungal Metabolites
  • É parte de: Letters in Organic Chemistry, 2010, Vol.7(5), p.353-359
  • Descrição: An efficient synthesis of the azetidinyl-thiazoline fragment of the antifungal and cytotoxic macrolides vioprolides A and C is reported. Key steps of the synthesis include formation of the thiazoline by condensation of N-Alloc- trans (2S,4R)-4-methylazetidine-2-carbonitrile with L-cysteine and formation of the four-membered ring by intramolecular alkylation of a suitably protected N-Alloc derivative prepared from (R)-alaninol.
  • Idioma: Inglês

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