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Neuroimaging markers of human immunodeficiency virus infection in South Africa

Heaps, Jodi ; Joska, John ; Hoare, Jackie ; Ortega, Mario ; Agrawal, Aleena ; Seedat, Soraya ; Ances, Beau ; Stein, Dan ; Paul, Robert

Journal of NeuroVirology, 2012, Vol.18(3), pp.151-156 [Periódico revisado por pares]

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  • Título:
    Neuroimaging markers of human immunodeficiency virus infection in South Africa
  • Autor: Heaps, Jodi ; Joska, John ; Hoare, Jackie ; Ortega, Mario ; Agrawal, Aleena ; Seedat, Soraya ; Ances, Beau ; Stein, Dan ; Paul, Robert
  • Assuntos: Clade C virus ; HIV infection ; South Africa ; Neuroimaging
  • É parte de: Journal of NeuroVirology, 2012, Vol.18(3), pp.151-156
  • Descrição: Previous studies have reported cognitive deficits among HIV-positive individuals infected with clade C virus. However, no study has examined whether individuals predominately infected with clade C virus exhibit brain atrophy relative to healthy controls. This study examined volumetric differences between 28 HIV+ individuals and 23 HIV− controls from South Africa. Volumetric measures were obtained from six regions of interest — caudate, thalamus, corpus callosum, total cortex, total gray matter, and total white matter. HIV+ participants had significantly lower volumes in the total white matter ( p  < 0.01), thalamus ( p  < 0.01) and total gray matter (inclusive of cortical and subcortical regions , p  < 0.01). This study is the first to provide evidence of brain atrophy among HIV+ individuals in South Africa, where HIV clade C predominates. Additional research that integrates neuroimaging, comprehensive neuropsychological testing, genetic variance in clade-specific proteins, and the impact of treatment with Antiretrovirals (ARV) are necessary to understand the development of HIV-related neurocognitive disorders in South Africa.
  • Idioma: Inglês

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