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Comparison of in vitro antifungal susceptibilities of conidia and hyphae of dermatophytes with thick-wall macroconidia

Fernández-Torres, Belkys ; Inza, Isabel ; Guarro, Josep

Antimicrobial agents and chemotherapy, October 2003, Vol.47(10), pp.3371-2 [Periódico revisado por pares]

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  • Título:
    Comparison of in vitro antifungal susceptibilities of conidia and hyphae of dermatophytes with thick-wall macroconidia
  • Autor: Fernández-Torres, Belkys ; Inza, Isabel ; Guarro, Josep
  • Assuntos: Antifungal Agents -- Pharmacology ; Arthrodermataceae -- Cytology
  • É parte de: Antimicrobial agents and chemotherapy, October 2003, Vol.47(10), pp.3371-2
  • Descrição: Although the invasive forms of filamentous fungi are generally hyphae, the reference methods (6) recommend the use of conidial suspensions, such as inocula. Some studies testing Aspergillus spp. have compared the MICs obtained with conidial suspensions with the MICs obtained with hyphal suspensions by using both forms of inocula, and the MICs were similar (1, 3, 7). This was probably because the thickness of the cell walls of the conidia and hyphae of the fungi tested were similar. However, in some fungi, such as several dermatophytes, the wall of the conidia is considerably thicker than the wall of the hyphae, and we do not know whether the antifungal susceptibilities of these two morphological forms would be different. We have compared how inocula of conidia and hyphae of five species of dermatophytes with thick-wall macroconidia affect the MICs of five antifungal agents.
  • Idioma: Inglês

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