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Methodologic approaches to evaluating new highly sensitive diagnostic tests: avoiding overdiagnosis.(ANALYSIS)(Report)

de Groot, Joris A.H. ; Naaktgeboren, Christiana A. ; Reitsma, Johannes B. ; Moons, Karel G.M.

CMAJ: Canadian Medical Association Journal, Jan 16, 2017, Vol.189(2), p.E64(5) [Periódico revisado por pares]

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  • Título:
    Methodologic approaches to evaluating new highly sensitive diagnostic tests: avoiding overdiagnosis.(ANALYSIS)(Report)
  • Autor: de Groot, Joris A.H. ; Naaktgeboren, Christiana A. ; Reitsma, Johannes B. ; Moons, Karel G.M.
  • Assuntos: Diagnosis – Methods
  • É parte de: CMAJ: Canadian Medical Association Journal, Jan 16, 2017, Vol.189(2), p.E64(5)
  • Descrição: Traditional cross-sectional studies of diagnostic accuracy that only employ the current reference standard are insufficient to evaluate the clinical relevance of many new highly sensitive tests. Appropriate methods for assessing the performance of these tests should be developed to overcome the challenges induced by present-day technologic developments. Improved data analysis and presentation of current studies of diagnostic accuracy, and better use of existing data are required. Test-treatment trials may be needed to measure the effectiveness or impact of new highly sensitive diagnostic tests on improving patient-relevant outcomes, to avoid the harms of overdiagnosis and overtreatment. The problem of overdiagnosis, in general, arises and persists due to multiple complex forces such as financial gain, legal concerns and media hype.5,6 Some have argued that millions of people may be receiving unwarranted and potentially harmful treatments and have advocated for fairer, more rational and...
  • Idioma: Inglês

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