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The inhibitory effect of a polymerisable cationic monomer on functional matrix metalloproteinases

Liu, Ning ; Li, Fang ; Chen, Yu-Jiang ; Zhang, Ling ; Lu, Shuai ; Kang, Jun-Jun ; Chen, Ji-Hua

Journal of dentistry, November 2013, Vol.41(11), pp.1101-1108 [Periódico revisado por pares]

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  • Título:
    The inhibitory effect of a polymerisable cationic monomer on functional matrix metalloproteinases
  • Autor: Liu, Ning ; Li, Fang ; Chen, Yu-Jiang ; Zhang, Ling ; Lu, Shuai ; Kang, Jun-Jun ; Chen, Ji-Hua
  • Assuntos: Dentine ; Matrix Metalloproteinase ; Quaternary Ammonium Compounds ; Inhibitor ; Hydroxyproline ; Collagen ; Dentine ; Matrix Metalloproteinase ; Quaternary Ammonium Compounds ; Inhibitor ; Hydroxyproline ; Collagen ; Dentistry
  • É parte de: Journal of dentistry, November 2013, Vol.41(11), pp.1101-1108
  • Descrição: This study examined the use of methacryloxylethyl cetyl dimethyl ammonium chloride (DMAE-CB) as a potential matrix metalloproteinases (MMPs) inhibitor on both soluble recombinant and dentine matrix-bound endogenous MMPs, meanwhile attempted to determine the effective anti-MMP group of quaternary ammonium methacrylates (QAMs). The possible inhibitory effects of five DMAE-CB mass concentrations (0.1%, 0.5%, 1%, 3%, 5%) on soluble rhMMP-9 were measured using a colorimetic assay kit. Methyl methacrylate (MMA) and [2-(methacryloyloxy)ethyl] trimethylammonium chloride (METMAC) were also screened against rhMMP-9 to compare the inhibitory effect with DMAE-CB. Matrix-bound endogenous MMP-activity was evaluated in completely demineralized dentine beams. Thirty beams were randomly divided into three groups (N=10) and respectively placed into 500μL of calcium- and zinc-containing media (CM; control), 0.2% chlorhexidine or 3% DMAE-CB in CM aged for 30 days. The changes in...
  • Idioma: Inglês

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