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In silico genome wide mining of conserved and novel miRNAs in the brain and pineal gland of Danio rerio using small RNA sequencing data

Agarwal, Suyash ; Nagpure, Naresh Sahebrao ; Srivastava, Prachi ; Kushwaha, Basdeo ; Kumar, Ravindra ; Pandey, Manmohan ; Srivastava, Shreya

Genomics Data, March 2016, Vol.7, pp.46-53 [Periódico revisado por pares]

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  • Título:
    In silico genome wide mining of conserved and novel miRNAs in the brain and pineal gland of Danio rerio using small RNA sequencing data
  • Autor: Agarwal, Suyash ; Nagpure, Naresh Sahebrao ; Srivastava, Prachi ; Kushwaha, Basdeo ; Kumar, Ravindra ; Pandey, Manmohan ; Srivastava, Shreya
  • Assuntos: Mirna ; Ncrnas ; Novel Mirs ; Phylogenetic Analysis ; Zebrafish ; Biology
  • É parte de: Genomics Data, March 2016, Vol.7, pp.46-53
  • Descrição: MicroRNAs (miRNAs) are small, non-coding RNA molecules that bind to the mRNA of the target genes and regulate the expression of the gene at the post-transcriptional level. Zebrafish is an economically important freshwater fish species globally considered as a good predictive model for studying human diseases and development. The present study focused on uncovering known as well as novel miRNAs, target prediction of the novel miRNAs and the differential expression of the known miRNA using the small RNA sequencing data of the brain and pineal gland (dark and light treatments) obtained from NCBI SRA. A total of 165, 151 and 145 known zebrafish miRNAs were found in the brain, pineal gland (dark treatment) and pineal gland (light treatment), respectively. Chromosomes 4 and 5 of zebrafish reference assembly GRCz10 were found to contain maximum number of miR genes. The miR-181a and miR-182 were found to be highly expressed in terms of number of reads in the brain and pineal gland, respectively....
  • Idioma: Inglês

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