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Pessary or Progesterone to Prevent Preterm delivery in women with short cervical length: the Quadruple P randomised controlled trial

Maud D. van Zijl ; Bouchra Koullali ; Christiana A. Naaktgeboren ; Ewoud Schuit ; Dick J. Bekedam ; Etelka Moll ; Martijn A. Oudijk ; Wilhelmina M. van Baal ; Marjon A. de Boer ; Henricus Visser ; Joris van Drongelen ; Flip W. van de Made ; Karlijn C. Vollebregt ; Moira A. Muller ; Mireille N. Bekker ; Jozien T. J. Brons ; Marieke Sueters ; Josje Langenveld ; Maureen T. Franssen ; Nico W. Schuitemaker

BMC pregnancy and childbirth, 01 September 2017, Vol.17(1), pp.1-8 [Periódico revisado por pares]

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Título:
Pessary or Progesterone to Prevent Preterm delivery in women with short cervical length: the Quadruple P randomised controlled trial
Autor: Maud D. van Zijl ; Bouchra Koullali ; Christiana A. Naaktgeboren ; Ewoud Schuit ; Dick J. Bekedam ; Etelka Moll ; Martijn A. Oudijk ; Wilhelmina M. van Baal ; Marjon A. de Boer ; Henricus Visser ; Joris van Drongelen ; Flip W. van de Made ; Karlijn C. Vollebregt ; Moira A. Muller ; Mireille N. Bekker ; Jozien T. J. Brons ; Marieke Sueters ; Josje Langenveld ; Maureen T. Franssen ; Nico W. Schuitemaker
Assuntos: Preterm Birth ; Singletons ; Multiples ; Prevention ; Pessary ; Progesterone ; Medicine
É parte de: BMC pregnancy and childbirth, 01 September 2017, Vol.17(1), pp.1-8
Descrição: Abstract Background Preterm birth is in quantity and in severity the most important topic in obstetric care in the developed world. Progestogens and cervical pessaries have been studied as potential preventive treatments with conflicting results. So far, no study has compared both treatments. Methods/design The Quadruple P study aims to compare the efficacy of vaginal progesterone and cervical pessary in the prevention of adverse perinatal outcome associated with preterm birth in asymptomatic women with a short cervix, in singleton and multiple pregnancies separately. It is a nationwide open-label multicentre randomized clinical trial (RCT) with a superiority design and will be accompanied by an economic analysis. Pregnant women undergoing the routine anomaly scan will be offered cervical length measurement between 18 and 22 weeks in a singleton and at 16–22 weeks in a multiple pregnancy. Women with a short cervix, defined as less than, or equal to 35 mm in a singleton and less...
Idioma: Inglês

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Pessary or Progesterone to Prevent Preterm delivery in women with short cervical length: the Quadruple P randomised controlled trial

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