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Transcription profiling provides insights into gene pathways involved in horn and scurs development in cattle

Lehnert Sigrid A ; Barris Wes ; Reverter Antonio ; Mariasegaram Maxy ; Dalrymple Brian ; Prayaga Kishore

BMC genomics, 01 June 2010, Vol.11(1), p.370 [Periódico revisado por pares]

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  • Título:
    Transcription profiling provides insights into gene pathways involved in horn and scurs development in cattle
  • Autor: Lehnert Sigrid A ; Barris Wes ; Reverter Antonio ; Mariasegaram Maxy ; Dalrymple Brian ; Prayaga Kishore
  • Assuntos: Biology
  • É parte de: BMC genomics, 01 June 2010, Vol.11(1), p.370
  • Descrição: Abstract Background Two types of horns are evident in cattle - fixed horns attached to the skull and a variation called scurs, which refers to small loosely attached horns. Cattle lacking horns are referred to as polled. Although both the Poll and Scurs loci have been mapped to BTA1 and 19 respectively, the underlying genetic basis of these phenotypes is unknown, and so far, no candidate genes regulating these developmental processes have been described. This study is the first reported attempt at transcript profiling to identify genes and pathways contributing to horn and scurs development in Brahman cattle, relative to polled counterparts. Results Expression patterns in polled, horned and scurs tissues were obtained using the Agilent 44 k bovine array. The most notable feature when comparing transcriptional profiles of developing horn tissues against polled was the down regulation of genes coding for elements of the cadherin junction as well as those involved in epidermal development....
  • Idioma: Inglês

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