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The revised Trypanosoma cruzi subspecific nomenclature: Rationale, epidemiological relevance and research applications

Zingales, Bianca ; Miles, Michael A. ; Campbell, David A. ; Tibayrenc, Michel ; Macedo, Andrea M. ; Teixeira, Marta M.G. ; Schijman, Alejandro G. ; Llewellyn, Martin S. ; Lages-Silva, Eliane ; Machado, Carlos R. ; Andrade, Sonia G. ; Sturm, Nancy R.

Infection, genetics and evolution, 2012-03, Vol.12 (2), p.240-253 [Periódico revisado por pares]

Kidlington: Elsevier B.V

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Título:
The revised Trypanosoma cruzi subspecific nomenclature: Rationale, epidemiological relevance and research applications
Autor: Zingales, Bianca ; Miles, Michael A. ; Campbell, David A. ; Tibayrenc, Michel ; Macedo, Andrea M. ; Teixeira, Marta M.G. ; Schijman, Alejandro G. ; Llewellyn, Martin S. ; Lages-Silva, Eliane ; Machado, Carlos R. ; Andrade, Sonia G. ; Sturm, Nancy R.
Assuntos: Animals ; Biological and medical sciences ; Chagas disease ; Chagas Disease - epidemiology ; Chagas Disease - parasitology ; Chiroptera - parasitology ; Discrete typing unit ; Epidemiology. Vaccinations ; Evolution, Molecular ; General aspects ; Genetic Variation ; genome ; Genome, Protozoan ; Genomics ; Genotyping ; human diseases ; Humans ; Hybridization ; Infectious diseases ; mammals ; Medical sciences ; Multilocus Sequence Typing ; parasites ; Pathology ; Phylogeography ; population structure ; public health ; Terminology as Topic ; Trypanosoma cruzi ; Trypanosoma cruzi - classification ; Trypanosoma cruzi - genetics ; Trypanosoma cruzi - pathogenicity ; Trypanosoma cruzi strains
É parte de: Infection, genetics and evolution, 2012-03, Vol.12 (2), p.240-253
Notas: http://dx.doi.org/10.1016/j.meegid.2011.12.009
ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
Descrição: ► We review the population structure of Trypanosoma cruzi, causative agent of Chagas disease. ► We provide information on the eco-epidemiology of T. cruzi discrete typing units (DTUs). ► We outline the correlation of DTU with clinical manifestations. ► We summarize methods for DTU genotyping. ► Understanding of T. cruzi genetic diversity will provide new insights to future interventions. The protozoan Trypanosoma cruzi, its mammalian reservoirs, and vectors have existed in nature for millions of years. The human infection, named Chagas disease, is a major public health problem for Latin America. T. cruzi is genetically highly diverse and the understanding of the population structure of this parasite is critical because of the links to transmission cycles and disease. At present, T. cruzi is partitioned into six discrete typing units (DTUs), TcI–TcVI. Here we focus on the current status of taxonomy-related areas such as population structure, phylogeographical and eco-epidemiological features, and the correlation of DTU with natural and experimental infection. We also summarize methods for DTU genotyping, available for widespread use in endemic areas. For the immediate future multilocus sequence typing is likely to be the gold standard for population studies. We conclude that greater advances in our knowledge on pathogenic and epidemiological features of these parasites are expected in the coming decade through the comparative analysis of the genomes from isolates of various DTUs.
Editor: Kidlington: Elsevier B.V
Idioma: Inglês

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The revised Trypanosoma cruzi subspecific nomenclature: Rationale, epidemiological relevance and research applications

Zingales, Bianca ; Miles, Michael A. ; Campbell, David A. ; Tibayrenc, Michel ; Macedo, Andrea M. ; Teixeira, Marta M.G. ; Schijman, Alejandro G. ; Llewellyn, Martin S. ; Lages-Silva, Eliane ; Machado, Carlos R. ; Andrade, Sonia G. ; Sturm, Nancy R.

Kidlington: Elsevier B.V

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