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Non-insulinoma pancreatogenous hypoglycemia syndrome (NIPHS)/Nesidioblastosis as the underlying cause of recurrent hypoglycemia in a diabetic adult

Thapa, Samikshya; Kaur, Kirandeep; Yadav, Gajendra Kumar; Kumari, Divya; Phulware, Ravi Hari

Autopsy and Case Reports; Vol. 13 (2023); e2023451

Universidade de São Paulo. Hospital Universitário 2023-10-27

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  • Título:
    Non-insulinoma pancreatogenous hypoglycemia syndrome (NIPHS)/Nesidioblastosis as the underlying cause of recurrent hypoglycemia in a diabetic adult
  • Autor: Thapa, Samikshya; Kaur, Kirandeep; Yadav, Gajendra Kumar; Kumari, Divya; Phulware, Ravi Hari
  • Assuntos: Nesidioblastosis; Hyperinsulinism; Hypoglycemia; Pancreatic Diseases; Nutritional And Metabolic Diseases
  • É parte de: Autopsy and Case Reports; Vol. 13 (2023); e2023451
  • Descrição: Non-insulinoma pancreatogenous hypoglycemia syndrome (NIPHS), without previous bariatric surgery, is a rare form of hypoglycemia in adult patients and is associated with nesidioblastosis. Adult-onset nesidioblastosis in diabetic patients is rare and histologically identical to "non-insulinoma pancreatogenous hypoglycemia syndrome (NIPHS)". Nesidioblastosis is rare in adults and clinically and biochemically mimics Insulinoma. In the literature, there have only been four cases of adult nesidioblastosis that followed diabetes mellitus. We report a case of nesidioblastosis in a 36-year-old diabetic female presenting with dizziness, sweating, and palpitations for three years. Selective non-invasive techniques failed to detect a tumor. Based on the pursuit of an insulinoma, a distal pancreatectomy specimen was received at our laboratory, and a diagnosis of nesidioblastosis was made. She is currently on follow-up with a favorable outcome. The definitive diagnosis of nesidioblastosis is made on a histological basis. The preferred form of treatment is pancreatic surgical resection. Nesidioblastosis should be taken into consideration in cases where diabetes transforms into hyperinsulinemic hypoglycemia.
  • Títulos relacionados: https://www.revistas.usp.br/autopsy/article/view/217827/199153
  • Editor: Universidade de São Paulo. Hospital Universitário
  • Data de criação/publicação: 2023-10-27
  • Formato: Adobe PDF
  • Idioma: Inglês
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