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Immunologic responses following administration of a vaccine targeting human papillomavirus Types 6, 11, 16, and 18

Villa, Luisa L. ; Ault, Kevin A. ; Giuliano, Anna R. ; Costa, Ronaldo L.R. ; Petta, Carlos A. ; Andrade, Rosires P. ; Brown, Darron R. ; Ferenczy, Alex ; Harper, Diane M. ; Koutsky, Laura A. ; Kurman, Robert J. ; Lehtinen, Matti ; Malm, Christian ; Olsson, Sven-Eric ; Ronnett, Brigitte M. ; Skjeldestad, Finn Egil ; Steinwall, Margareta ; Stoler, Mark H. ; Wheeler, Cosette M. ; Taddeo, Frank J. ; Yu, Jimmy ; Lupinacci, Lisa ; Railkar, Radha ; Marchese, Rocio ; Esser, Mark T. ; Bryan, Janine ; Jansen, Kathrin U. ; Sings, Heather L. ; Tamms, Gretchen M. ; Saah, Alfred J. ; Barr, Eliav

Vaccine, 2006-07, Vol.24 (27), p.5571-5583 [Periódico revisado por pares]

Oxford: Elsevier Ltd

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Título:
Immunologic responses following administration of a vaccine targeting human papillomavirus Types 6, 11, 16, and 18
Autor: Villa, Luisa L. ; Ault, Kevin A. ; Giuliano, Anna R. ; Costa, Ronaldo L.R. ; Petta, Carlos A. ; Andrade, Rosires P. ; Brown, Darron R. ; Ferenczy, Alex ; Harper, Diane M. ; Koutsky, Laura A. ; Kurman, Robert J. ; Lehtinen, Matti ; Malm, Christian ; Olsson, Sven-Eric ; Ronnett, Brigitte M. ; Skjeldestad, Finn Egil ; Steinwall, Margareta ; Stoler, Mark H. ; Wheeler, Cosette M. ; Taddeo, Frank J. ; Yu, Jimmy ; Lupinacci, Lisa ; Railkar, Radha ; Marchese, Rocio ; Esser, Mark T. ; Bryan, Janine ; Jansen, Kathrin U. ; Sings, Heather L. ; Tamms, Gretchen M. ; Saah, Alfred J. ; Barr, Eliav
Assuntos: Adolescent ; Adult ; Antibodies, Viral - biosynthesis ; Antibodies, Viral - immunology ; Applied microbiology ; Biological and medical sciences ; Cervical cancer ; Clinical Medicine ; Double-Blind Method ; Female ; Fundamental and applied biological sciences. Psychology ; Human papillomavirus ; Human papillomavirus 11 ; Human papillomavirus 11 - immunology ; Human papillomavirus 16 ; Human papillomavirus 16 - immunology ; Human papillomavirus 18 ; Human papillomavirus 18 - immunology ; Human papillomavirus 6 ; Human papillomavirus 6 - immunology ; Humans ; Immunization ; Immunogenicity ; Klinisk medicin ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Microbiology ; Miscellaneous ; Obstetrics, Gynecology and Reproductive Medicine ; Papillomaviridae - classification ; Papillomaviridae - immunology ; Papillomavirus Infections - immunology ; Papillomavirus Infections - virology ; Papillomavirus Vaccines ; Reproduktionsmedicin och gynekologi ; Vaccine ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Viral Vaccines - administration & dosage ; Viral Vaccines - adverse effects ; Viral Vaccines - immunology ; Virology
É parte de: Vaccine, 2006-07, Vol.24 (27), p.5571-5583
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Descrição: Human papillomavirus (HPV) infection causes cervical cancer and genital warts. Young women (1106) were randomized to receive one of three formulations of a quadrivalent HPV (Types 6/11/16/18) L1 virus-like particle (VLP) vaccine or one of two placebo formulations. The goal was to assess vaccine safety and immunogenicity in baseline HPV 6/11/16 or 18-naïve and previously infected subjects. All three formulations were highly immunogenic. At Month 2 (postdose 1), among women with vaccine-type antibodies at baseline, vaccine-induced anti-HPV responses were ∼12- to 26-fold higher than those observed in baseline-naïve women, suggesting an anamnestic response. Following an initial, similar sized decline, anti-HPV responses plateaued and remained stable through end-of-study (3.0 years). No vaccine-related serious adverse experiences were reported.
Editor: Oxford: Elsevier Ltd
Idioma: Inglês

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Immunologic responses following administration of a vaccine targeting human papillomavirus Types 6, 11, 16, and 18

Oxford: Elsevier Ltd

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