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Diagnostic value of plasma phosphorylated tau181 in Alzheimer's disease and frontotemporal lobar degeneration

Thijssen, Elisabeth H ; La Joie, Renaud ; Wolf, Amy ; Strom, Amelia ; Wang, Ping ; Iaccarino, Leonardo ; Bourakova, Viktoriya ; Cobigo, Yann ; Heuer, Hilary ; Spina, Salvatore ; VandeVrede, Lawren ; Chai, Xiyun ; Proctor, Nicholas K ; Airey, David C ; Shcherbinin, Sergey ; Duggan Evans, Cynthia ; Sims, John R ; Zetterberg, Henrik ; Blennow, Kaj ; Karydas, Anna M ; Teunissen, Charlotte E ; Kramer, Joel H ; Grinberg, Lea T ; Seeley, William W ; Rosen, Howie ; Boeve, Bradley F ; Miller, Bruce L ; Rabinovici, Gil D ; Dage, Jeffrey L ; Rojas, Julio C ; Boxer, Adam L

Nature medicine, 2020-03, Vol.26 (3), p.387-397 [Periódico revisado por pares]

United States: Nature Publishing Group

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Diagnostic value of plasma phosphorylated tau181 in Alzheimer's disease and frontotemporal lobar degeneration
Autor: Thijssen, Elisabeth H ; La Joie, Renaud ; Wolf, Amy ; Strom, Amelia ; Wang, Ping ; Iaccarino, Leonardo ; Bourakova, Viktoriya ; Cobigo, Yann ; Heuer, Hilary ; Spina, Salvatore ; VandeVrede, Lawren ; Chai, Xiyun ; Proctor, Nicholas K ; Airey, David C ; Shcherbinin, Sergey ; Duggan Evans, Cynthia ; Sims, John R ; Zetterberg, Henrik ; Blennow, Kaj ; Karydas, Anna M ; Teunissen, Charlotte E ; Kramer, Joel H ; Grinberg, Lea T ; Seeley, William W ; Rosen, Howie ; Boeve, Bradley F ; Miller, Bruce L ; Rabinovici, Gil D ; Dage, Jeffrey L ; Rojas, Julio C ; Boxer, Adam L
Assuntos: Aged ; Alzheimer Disease - blood ; Alzheimer Disease - cerebrospinal fluid ; Alzheimer Disease - diagnosis ; Alzheimer's disease ; Alzheimers disease ; Amyloid ; Amyloid - metabolism ; Amyloid beta-Peptides - blood ; Amyloid beta-Peptides - cerebrospinal fluid ; amyloid pet ; Aphasia ; association workgroups ; Autopsies ; Autopsy ; Biochemistry & Molecular Biology ; Biochemistry and Molecular Biology ; Biokemi och molekylärbiologi ; Biomarkers ; Biomarkers - blood ; Biomarkers - cerebrospinal fluid ; Blood ; Brain research ; Cell Biology ; Cerebral cortex ; Cerebrospinal fluid ; Cognition ; Cognitive ability ; csf biomarkers ; Degeneration ; Dementia ; Diagnosis ; Diagnostic systems ; Disease control ; Emission analysis ; Evaluation ; Female ; fluid biomarkers ; Frontotemporal dementia ; Frontotemporal Lobar Degeneration - blood ; Frontotemporal Lobar Degeneration - diagnosis ; Frontotemporal Lobar Degeneration - genetics ; Frontotemporal Lobar Degeneration - pathology ; Geriatrics ; Gray Matter - diagnostic imaging ; Gray Matter - pathology ; Heterozygote ; Humans ; impairment ; Laboratories ; Male ; Measurement ; Medical examination ; Medicine ; Middle Aged ; mild cognitive ; Mutation ; Mutation - genetics ; national institute ; Neurochemistry ; Neurodegenerative diseases ; neurofilament light-chain ; Neurofilament Proteins - blood ; Neurology ; neuropathology ; Neurosciences ; Pathology ; Phosphorylation ; Plasma ; Positron emission ; Positron emission tomography ; Research & Experimental ; Severity of Illness Index ; Signs and symptoms ; Tau protein ; Tau proteins ; tau Proteins - blood ; tau Proteins - cerebrospinal fluid ; tau Proteins - genetics ; Tomography
É parte de: Nature medicine, 2020-03, Vol.26 (3), p.387-397
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Concept and design: E.H.T., J.L.D, J.C.R., A.L.B.
Critical revision of the manuscript for important intellectual content: E.H.T., R.L.J., J.L.D., J.C.R., A.L.B.
E.H.T. and J.C.R. had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Acquisition, analysis, or interpretation of data: All authors.
Obtained funding: A.L.B., B.F.B., H.R., B.L.M., G.D.R., J.H.K., J.L.D.
Supervision: J.L.D., J.C.R., A.L.B.
Drafting of the manuscript: E.H.T.
Statistical analysis: E.H.T., R.L.J., P.W., D.C.A., J.C.R.
Author contributions
Descrição: With the potential development of new disease-modifying Alzheimer's disease (AD) therapies, simple, widely available screening tests are needed to identify which individuals, who are experiencing symptoms of cognitive or behavioral decline, should be further evaluated for initiation of treatment. A blood-based test for AD would be a less invasive and less expensive screening tool than the currently approved cerebrospinal fluid or amyloid β positron emission tomography (PET) diagnostic tests. We examined whether plasma tau phosphorylated at residue 181 (pTau181) could differentiate between clinically diagnosed or autopsy-confirmed AD and frontotemporal lobar degeneration. Plasma pTau181 concentrations were increased by 3.5-fold in AD compared to controls and differentiated AD from both clinically diagnosed (receiver operating characteristic area under the curve of 0.894) and autopsy-confirmed frontotemporal lobar degeneration (area under the curve of 0.878). Plasma pTau181 identified individuals who were amyloid β-PET-positive regardless of clinical diagnosis and correlated with cortical tau protein deposition measured by F-flortaucipir PET. Plasma pTau181 may be useful to screen for tau pathology associated with AD.
Editor: United States: Nature Publishing Group
Idioma: Inglês

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Diagnostic value of plasma phosphorylated tau181 in Alzheimer's disease and frontotemporal lobar degeneration

United States: Nature Publishing Group

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