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First Paleogenetic Evidence of Probable Syphilis and Treponematoses Cases in the Brazilian Colonial Period

Guedes, Lucélia ; Dias, Ondemar ; Neto, Jandira ; Ribeiro da Silva, Laura da Piedade ; Mendonça de Souza, Sheila M. F. ; Iñiguez, Alena Mayo Fujita, Hisashi ; Hisashi Fujita

BioMed research international, 2018-01, Vol.2018, p.8304129-8 [Periódico revisado por pares]

United States: Hindawi

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Título:
First Paleogenetic Evidence of Probable Syphilis and Treponematoses Cases in the Brazilian Colonial Period
Autor: Guedes, Lucélia ; Dias, Ondemar ; Neto, Jandira ; Ribeiro da Silva, Laura da Piedade ; Mendonça de Souza, Sheila M. F. ; Iñiguez, Alena Mayo
Fujita, Hisashi ; Hisashi Fujita
Assuntos: 19th century ; Adolescent ; Adult ; Adults ; Archaeological sites ; Archaeology ; Base Sequence ; Book publishing ; Brazil ; Collaboration ; Data points ; Data processing ; Deoxyribonucleic acid ; DNA ; Epidemiology ; Female ; Gene sequencing ; Genomes ; Globus pallidus ; Health aspects ; Historic sites ; History, 17th Century ; History, 18th Century ; History, 19th Century ; Human remains ; Humans ; Hypotheses ; Infection ; Infections ; Infectious diseases ; Infectivity ; Male ; Nucleotide sequence ; Paleopathology ; Polymorphism ; Sexually transmitted diseases ; STD ; Syphilis ; Syphilis - genetics ; Syphilis - history ; Syphilis - pathology ; Treponema ; Treponema - genetics ; Treponemal Infections - genetics ; Treponemal Infections - history ; Treponemal Infections - pathology ; Treponematosis ; Yaws ; Young Adult ; Young adults
É parte de: BioMed research international, 2018-01, Vol.2018, p.8304129-8
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Guest Editor: Hisashi Fujita
Descrição: Despite interest in the origins of syphilis, paleopathological analysis has not provided answers, and paleogenetic diagnosis remains a challenge. Even venereal syphilis has low infectivity which means there are few circulating bacteria for most of the individual’s life. Human remains recovered from the Nossa Senhora do Carmo Church (17th to 19th centuries) and the Praça XV Cemetery (18th to 19th centuries), Rio de Janeiro, Brazil, were subjected to Treponema paleogenetic analysis. Historical data point to endemic treponemal infections in the city, including venereal syphilis. Based on the physiopathology of Treponema pallidum infection, 25 samples, mostly from skull remains of young adults, with no visible paleopathological evidence of treponematoses, were analyzed. PCR with three molecular targets, tpp47, polA, and tpp15, were applied. Ancient DNA tpp15 sequences were recovered from two young adults from each archaeological site and revealed the polymorphism that characterizes T. p. subsp. pallidum in a female up to 18 years old, suggesting a probable case of syphilis infection. The results indicated that the epidemiological context and the physiopathology of the disease should be considered in syphilis paleogenetic detection. The findings of Treponema sp. aDNA are consistent with historical documents that describe venereal syphilis and yaws as endemic diseases in Rio de Janeiro. Data on the epidemiological characteristics of the disease and its pathophysiology offer new perspectives in paleopathology.
Editor: United States: Hindawi
Idioma: Inglês

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First Paleogenetic Evidence of Probable Syphilis and Treponematoses Cases in the Brazilian Colonial Period

Guedes, Lucélia ; Dias, Ondemar ; Neto, Jandira ; Ribeiro da Silva, Laura da Piedade ; Mendonça de Souza, Sheila M. F. ; Iñiguez, Alena Mayo Fujita, Hisashi ; Hisashi Fujita

United States: Hindawi

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