Idioma:

Relationship Between Gastric Emptying and Diurnal Glycemic Control in Type 1 Diabetes Mellitus: A Randomized Trial

Parthasarathy, Gopanandan ; Kudva, Yogish C ; Low, Phillip A ; Camilleri, Michael ; Basu, Ananda ; Bharucha, Adil E

The journal of clinical endocrinology and metabolism, 2017-02, Vol.102 (2), p.398-406 [Periódico revisado por pares]

Washington, DC: Endocrine Society

Texto completo disponível

Citações Citado por

Enviar para

Título:
Relationship Between Gastric Emptying and Diurnal Glycemic Control in Type 1 Diabetes Mellitus: A Randomized Trial
Autor: Parthasarathy, Gopanandan ; Kudva, Yogish C ; Low, Phillip A ; Camilleri, Michael ; Basu, Ananda ; Bharucha, Adil E
Assuntos: Adult ; Aged ; Blood Glucose - metabolism ; Blood Glucose Self-Monitoring - methods ; Carbohydrates ; Circadian Rhythm - physiology ; Clinical s ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (insulin dependent) ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - drug therapy ; Diabetes Mellitus, Type 1 - physiopathology ; Dietary Carbohydrates - administration & dosage ; Diurnal ; Drug Administration Schedule ; Emptying ; Erythromycin ; Erythromycin - pharmacology ; Female ; Gastric emptying ; Gastric Emptying - drug effects ; Gastric Emptying - physiology ; Gastrointestinal Agents - pharmacology ; Glucose ; Health care facilities ; Hemoglobin ; Humans ; Hyperglycemia ; Hypoglycemia ; Hypoglycemic Agents - administration & dosage ; Insulin ; Insulin - administration & dosage ; Intravenous administration ; Male ; Middle Aged ; Young Adult
É parte de: The journal of clinical endocrinology and metabolism, 2017-02, Vol.102 (2), p.398-406
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-News-1
ObjectType-Feature-3
content type line 23
Mayo Clinic does not endorse specific products or services included in this article.
Descrição: Context:In type 1 diabetes (T1D), delayed gastric emptying (GE) may predispose to a mismatch between insulin delivery and glucose absorption. Previous studies evaluated, only partly, the relationship between delayed GE and postprandial, but not diurnal, glycemia.Objective:To assess the relationship between GE disturbances and glycemic control in T1D and the effects of accelerating GE on glycemic control.Design, Setting and Participants: This was a randomized placebo-controlled trial in 30 patients with T1D on an insulin pump at an academic medical center.Intervention(s):GE was evaluated with a [13C]-Spirulina breath test at baseline (GEbaseline), during intravenous saline or erythromycin (2 or 3 mg/kg) (GEiv), and after 7 days of oral erythromycin or placebo (GEoral). Weighed meals were provided throughout the study.Main Outcome Measure(s):GE, Continuous glucose monitoring (CGM)Results:The baseline HbA1c was 7.6%±0.8% (60±8.7 mmol/mol); 12 patients (40%) had delayed GE; faster GE was associated with a greater postprandial CGM-based glucose, but slower GE was not associated with postprandial hypoglycemia (<70 mg/dL). Intravenous (3 mg/kg) but not oral erythromycin accelerated GE. The relationship between GE and glycemia was different between the postprandial periods and the entire day. After adjusting for carbohydrate intake and insulin consumption, faster GE was associated with more hyperglycemia during the postprandial period. Across the entire study, CGM-based glucose values were lower in patients with faster GE.Conclusions:In T1D, pharmacologically mediated acceleration of GE increases postprandial CGM-based glucose. In contrast, delayed GE is associated with greater CGM-based glucose values over the entire day.
Editor: Washington, DC: Endocrine Society
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 7 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Relationship Between Gastric Emptying and Diurnal Glycemic Control in Type 1 Diabetes Mellitus: A Randomized Trial

Parthasarathy, Gopanandan ; Kudva, Yogish C ; Low, Phillip A ; Camilleri, Michael ; Basu, Ananda ; Bharucha, Adil E

Washington, DC: Endocrine Society

Buscando em bases de dados remotas. Favor aguardar.