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Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity

Jeffery, Elise ; Church, Christopher D ; Holtrup, Brandon ; Colman, Laura ; Rodeheffer, Matthew S

Nature cell biology, 2015-04, Vol.17 (4), p.376-385 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity
Autor: Jeffery, Elise ; Church, Christopher D ; Holtrup, Brandon ; Colman, Laura ; Rodeheffer, Matthew S
Assuntos: Adipocytes, White - cytology ; Adipocytes, White - metabolism ; Adipogenesis - drug effects ; Adipogenesis - genetics ; Adipogenesis - physiology ; Adipose Tissue, White ; Adipose tissues ; Androstadienes - pharmacology ; Animals ; Cell Proliferation - drug effects ; Cell Proliferation - genetics ; Development and progression ; Diet, High-Fat ; Eating ; Genetic aspects ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Obesity ; Obesity - metabolism ; Phosphatidylinositol 3-Kinases - metabolism ; Phosphoinositide-3 Kinase Inhibitors ; Properties ; Proto-Oncogene Proteins c-akt - genetics ; Proto-Oncogene Proteins c-akt - metabolism ; Random Allocation ; Tamoxifen - pharmacology ; Wortmannin
É parte de: Nature cell biology, 2015-04, Vol.17 (4), p.376-385
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SourceType-Scholarly Journals-1
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Descrição: Excessive accumulation of white adipose tissue (WAT) is the defining characteristic of obesity. WAT mass is composed primarily of mature adipocytes, which are generated through the proliferation and differentiation of adipocyte precursors (APs). Although the production of new adipocytes contributes to WAT growth in obesity, little is known about the cellular and molecular mechanisms underlying adipogenesis in vivo. Here, we show that high-fat diet feeding in mice rapidly and transiently induces proliferation of APs within WAT to produce new adipocytes. Importantly, the activation of adipogenesis is specific to the perigonadal visceral depot in male mice, consistent with the patterns of obesogenic WAT growth observed in humans. Furthermore, we find that in multiple models of obesity, the activation of APs is dependent on the phosphoinositide 3-kinase (PI3K)-AKT2 pathway; however, the development of WAT does not require AKT2. These data indicate that developmental and obesogenic adipogenesis are regulated through distinct molecular mechanisms.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity

Jeffery, Elise ; Church, Christopher D ; Holtrup, Brandon ; Colman, Laura ; Rodeheffer, Matthew S

England: Nature Publishing Group

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