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Persistent occult hepatitis B virus infection： Experimental findings and clinical implications

Patricia M Mulrooney-Cousins Tomasz I Michalak

World journal of gastroenterology : WJG, 2007-11, Vol.13 (43), p.5682-5686

United States: Molecular Virology and Hepatology Research, Division of BioMedical Science, Faculty of Medicine, Health Sciences Centre, Memorial University, St. John's, NL Al B 3V6, Canada

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  • Título:
    Persistent occult hepatitis B virus infection： Experimental findings and clinical implications
  • Autor: Patricia M Mulrooney-Cousins Tomasz I Michalak
  • Assuntos: Animals ; Disease Models, Animal ; Disease Progression ; Hepatitis B - complications ; Hepatitis B - diagnosis ; Hepatitis B - immunology ; Hepatitis B virus - immunology ; Hepatitis B virus - pathogenicity ; Hepatitis B Virus, Woodchuck - immunology ; Hepatitis B Virus, Woodchuck - pathogenicity ; Humans ; 滤过性毒菌 ; 肝炎病毒
  • É parte de: World journal of gastroenterology : WJG, 2007-11, Vol.13 (43), p.5682-5686
  • Notas: Virus reactivation
    Hepadnavirus lymphotropism
    Secondary occult infection
    14-1219/R
    R575.1
    Hepadnaviruses
    Occult viral persistence
    Hepadnaviral hepatitis
    Hepatitis B viWoodchuck hepatitis virus
    Hepatitis B viWoodchuck hepatitis virus; Hepadnaviruses;Hepadnaviral hepatitis;Occult viral persistence; Hepadnavirus lymphotropism;Primary occult infection; Secondary occult infection;Virus reactivation
    Primary occult infection
    SourceType-Scholarly Journals-1
    ObjectType-Commentary-2
    content type line 23
    ObjectType-Review-1
    ObjectType-Editorial-3
    Correspondence to: Tomasz I Michalak, MD, PhD, Molecular Virology and Hepatology Research, Faculty of Medicine, Health Science Centre, Memorial University, 300 Prince Philip Drive, St. John’s, NL A1B 3V6, Canada. timich@mun.ca
    Author contributions: All authors contributed equally to the work.
    Telephone: +1-709-7777301 Fax: +1-709-7778279
  • Descrição: Hepatitis B virus （HBV） is a highly pathogenic virus that causes chronic liver diseases in millions of people globally. In addition to a symptomatic, serologically evident infection, occult persistent HBV carriage has been identified since nucleic acid amplification assays of enhanced sensitivity became introduced for detection of hepadnaviral genomes and their replicative intermediates. Current evidence indicates that occult HBV infection is a common and long-term consequence of resolution of acute hepatitis B. This form of residual infection is termed as secondary occult infection （SOI）. The data from the woodchuck model of HBV infection indicate that exposure to small amounts of hepadnavirus can also cause primary occult infection （POI） where virus genome, but no serological makers of exposure to virus, are detectable, and the liver may not be involved. However, virus replicates at low levels in the lymphatic system in both these forms. We briefly summarize the current understanding of the nature and characteristics of occult hepadnaviral persistence as well as of its documented and expected pathological consequences.
  • Editor: United States: Molecular Virology and Hepatology Research, Division of BioMedical Science, Faculty of Medicine, Health Sciences Centre, Memorial University, St. John's, NL Al B 3V6, Canada
  • Idioma: Inglês
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