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ARID1A Mutations in Endometriosis-Associated Ovarian Carcinomas

Wiegand, Kimberly C ; Shah, Sohrab P ; Al-Agha, Osama M ; Zhao, Yongjun ; Tse, Kane ; Zeng, Thomas ; Senz, Janine ; McConechy, Melissa K ; Anglesio, Michael S ; Kalloger, Steve E ; Yang, Winnie ; Heravi-Moussavi, Alireza ; Giuliany, Ryan ; Chow, Christine ; Fee, John ; Zayed, Abdalnasser ; Prentice, Leah ; Melnyk, Nataliya ; Turashvili, Gulisa ; Delaney, Allen D ; Madore, Jason ; Yip, Stephen ; McPherson, Andrew W ; Ha, Gavin ; Bell, Lynda ; Fereday, Sian ; Tam, Angela ; Galletta, Laura ; Tonin, Patricia N ; Provencher, Diane ; Miller, Dianne ; Jones, Steven J.M ; Moore, Richard A ; Morin, Gregg B ; Oloumi, Arusha ; Boyd, Niki ; Aparicio, Samuel A ; Shih, Ie-Ming ; Mes-Masson, Anne-Marie ; Bowtell, David D ; Hirst, Martin ; Gilks, Blake ; Marra, Marco A ; Huntsman, David G

The New England journal of medicine, 2010-10, Vol.363 (16), p.1532-1543 [Periódico revisado por pares]

Waltham, MA: Massachusetts Medical Society

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Título:
ARID1A Mutations in Endometriosis-Associated Ovarian Carcinomas
Autor: Wiegand, Kimberly C ; Shah, Sohrab P ; Al-Agha, Osama M ; Zhao, Yongjun ; Tse, Kane ; Zeng, Thomas ; Senz, Janine ; McConechy, Melissa K ; Anglesio, Michael S ; Kalloger, Steve E ; Yang, Winnie ; Heravi-Moussavi, Alireza ; Giuliany, Ryan ; Chow, Christine ; Fee, John ; Zayed, Abdalnasser ; Prentice, Leah ; Melnyk, Nataliya ; Turashvili, Gulisa ; Delaney, Allen D ; Madore, Jason ; Yip, Stephen ; McPherson, Andrew W ; Ha, Gavin ; Bell, Lynda ; Fereday, Sian ; Tam, Angela ; Galletta, Laura ; Tonin, Patricia N ; Provencher, Diane ; Miller, Dianne ; Jones, Steven J.M ; Moore, Richard A ; Morin, Gregg B ; Oloumi, Arusha ; Boyd, Niki ; Aparicio, Samuel A ; Shih, Ie-Ming ; Mes-Masson, Anne-Marie ; Bowtell, David D ; Hirst, Martin ; Gilks, Blake ; Marra, Marco A ; Huntsman, David G
Assuntos: Adenocarcinoma, Clear Cell - genetics ; Adenocarcinoma, Clear Cell - metabolism ; Adenocarcinoma, Clear Cell - pathology ; Biological and medical sciences ; Cancer ; Carcinoma, Endometrioid - genetics ; Carcinoma, Endometrioid - metabolism ; Carcinoma, Endometrioid - pathology ; Care and treatment ; Causes of ; Cell Line, Tumor ; Endometriosis ; Endometriosis - complications ; Endometriosis - pathology ; Female ; Female genital diseases ; Gene Expression ; Gene Expression Profiling ; Gene mutations ; General aspects ; Genes, Tumor Suppressor ; Genetic aspects ; Gynecology. Andrology. Obstetrics ; Humans ; Medical research ; Medical sciences ; Mutation ; Non tumoral diseases ; Nuclear Proteins - genetics ; Nuclear Proteins - metabolism ; Ovarian cancer ; Ovarian Neoplasms - genetics ; Ovarian Neoplasms - metabolism ; Ovarian Neoplasms - pathology ; Sequence Analysis, RNA ; Transcription Factors - genetics ; Transcription Factors - metabolism ; Tumor suppressor genes ; Tumors
É parte de: The New England journal of medicine, 2010-10, Vol.363 (16), p.1532-1543
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: In this study of ovarian clear-cell or endometrioid tumors, nearly half the samples had mutations in the ARID1A gene, which encodes a component of the SWI–SNF chromatin remodeling complex. Alterations in gene expression associated with abnormal chromatin remodeling may be linked with cancer. In the United States, ovarian cancer ranks as the fifth deadliest cancer among women. 1 Of the several subtypes of epithelial ovarian cancer, high-grade serous carcinomas are the most common, accounting for approximately 70% of all cases of epithelial ovarian cancer in North America. 2 Although ovarian clear-cell carcinoma is the second most common subtype in North America (accounting for 12% of cases and an even higher percentage in Japan 3 ) and is the second leading cause of death from ovarian cancer, 2 it is relatively understudied. Ovarian clear-cell carcinoma is defined on the basis of histopathological findings, including a predominance of clear . . .
Editor: Waltham, MA: Massachusetts Medical Society
Idioma: Inglês

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ARID1A Mutations in Endometriosis-Associated Ovarian Carcinomas

Waltham, MA: Massachusetts Medical Society

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