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5G2 mutant mice model loss of a commonly deleted segment of chromosome 7q22 in myeloid malignancies

Wong, Jasmine C ; Weinfurtner, Kelley M ; Westover, Tamara ; Kim, Jangkyung ; Lebish, Eric J ; Del Pilar Alzamora, Maria ; Huang, Benjamin J ; Walsh, Michael ; Abdelhamed, Sherif ; Ma, Jing ; Klco, Jeffery M ; Shannon, Kevin

Leukemia, 2024-05, Vol.38 (5), p.1182-1186 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
5G2 mutant mice model loss of a commonly deleted segment of chromosome 7q22 in myeloid malignancies
Autor: Wong, Jasmine C ; Weinfurtner, Kelley M ; Westover, Tamara ; Kim, Jangkyung ; Lebish, Eric J ; Del Pilar Alzamora, Maria ; Huang, Benjamin J ; Walsh, Michael ; Abdelhamed, Sherif ; Ma, Jing ; Klco, Jeffery M ; Shannon, Kevin
Assuntos: Acute myeloid leukemia ; Alkylation ; Animals ; Blood diseases ; Cell cycle ; Cell division ; Chromosome 7 ; Chromosome Deletion ; Chromosomes ; Chromosomes, Human, Pair 7 - genetics ; Competition ; Cooperation ; Disease Models, Animal ; Gene deletion ; Genes ; Hematological diseases ; Hematopoiesis ; Hematopoietic stem cells ; Hemopoiesis ; Humans ; Letter ; Leukemia ; Leukemia, Myeloid, Acute - genetics ; Leukemia, Myeloid, Acute - pathology ; Leukemogenesis ; Malignancy ; Mice ; Mice, Inbred C57BL ; Monosomy ; Mutation ; Myelodysplastic Syndromes - genetics ; Myelodysplastic Syndromes - pathology ; Neoplasms ; Radiation ; Segments ; Stem cells ; Synteny ; Transplants & implants ; Tumors
É parte de: Leukemia, 2024-05, Vol.38 (5), p.1182-1186
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Descrição: Monosomy 7 and del(7q) are among the most common and poorly understood genetic alterations in myelodysplastic neoplasms and acute myeloid leukemia. Chromosome band 7q22 is a minimally deleted segment in myeloid malignancies with a del(7q). However, the rarity of "second hit" mutations supports the idea that del(7q22) represents a contiguous gene syndrome. We generated mice harboring a 1.5 Mb germline deletion of chromosome band 5G2 syntenic to human 7q22 that removes Cux1 and 27 additional genes. Hematopoiesis is perturbed in 5G2 mice but they do not spontaneously develop hematologic disease. Whereas alkylator exposure modestly accelerated tumor development, the 5G2 deletion did not cooperate with Kras , Nras , or the MOL4070LTR retrovirus in leukemogenesis. 5G2 mice are a novel platform for interrogating the role of hemopoietic stem cell attrition/stress, cooperating mutations, genotoxins, and inflammation in myeloid malignancies characterized by monosomy 7/del(7q).
Editor: England: Nature Publishing Group
Idioma: Inglês

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5G2 mutant mice model loss of a commonly deleted segment of chromosome 7q22 in myeloid malignancies

Wong, Jasmine C ; Weinfurtner, Kelley M ; Westover, Tamara ; Kim, Jangkyung ; Lebish, Eric J ; Del Pilar Alzamora, Maria ; Huang, Benjamin J ; Walsh, Michael ; Abdelhamed, Sherif ; Ma, Jing ; Klco, Jeffery M ; Shannon, Kevin

England: Nature Publishing Group

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