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An ancestral molecular response to nanomaterial particulates

Del Giudice, G ; Serra, A ; Saarimäki, L A ; Kotsis, K ; Rouse, I ; Colibaba, S A ; Jagiello, K ; Mikolajczyk, A ; Fratello, M ; Papadiamantis, A G ; Sanabria, N ; Annala, M E ; Morikka, J ; Kinaret, P A S ; Voyiatzis, E ; Melagraki, G ; Afantitis, A ; Tämm, K ; Puzyn, T ; Gulumian, M ; Lobaskin, V ; Lynch, I ; Federico, A ; Greco, D

Nature nanotechnology, 2023-08, Vol.18 (8), p.957-966 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
An ancestral molecular response to nanomaterial particulates
Autor: Del Giudice, G ; Serra, A ; Saarimäki, L A ; Kotsis, K ; Rouse, I ; Colibaba, S A ; Jagiello, K ; Mikolajczyk, A ; Fratello, M ; Papadiamantis, A G ; Sanabria, N ; Annala, M E ; Morikka, J ; Kinaret, P A S ; Voyiatzis, E ; Melagraki, G ; Afantitis, A ; Tämm, K ; Puzyn, T ; Gulumian, M ; Lobaskin, V ; Lynch, I ; Federico, A ; Greco, D
Assuntos: Analysis ; Binding sites ; Cellular stress response ; Chromatin remodeling ; Deregulation ; Exposure ; Gene regulation ; Immune system ; Immunomodulation ; Impact analysis ; Innate immunity ; Nanomaterials ; Nanoparticles ; Nanotechnology ; Particulates ; Protein folding ; Transcription factors ; Transcriptomics ; Zinc finger proteins
É parte de: Nature nanotechnology, 2023-08, Vol.18 (8), p.957-966
Descrição: The varied transcriptomic response to nanoparticles has hampered the understanding of the mechanism of action. Here, by performing a meta-analysis of a large collection of transcriptomics data from various engineered nanoparticle exposure studies, we identify common patterns of gene regulation that impact the transcriptomic response. Analysis identifies deregulation of immune functions as a prominent response across different exposure studies. Looking at the promoter regions of these genes, a set of binding sites for zinc finger transcription factors C H , involved in cell stress responses, protein misfolding and chromatin remodelling and immunomodulation, is identified. The model can be used to explain the outcomes of mechanism of action and is observed across a range of species indicating this is a conserved part of the innate immune system.
Editor: England: Nature Publishing Group
Idioma: Inglês

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An ancestral molecular response to nanomaterial particulates

England: Nature Publishing Group

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