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CGRP upregulation in dorsal root ganglia and ileal mucosa during Clostridium difficile toxin A-induced enteritis

Keates, A C ; Castagliuolo, I ; Qiu, B ; Nikulasson, S ; Sengupta, A ; Pothoulakis, C

The American journal of physiology, 1998-01, Vol.274 (1), p.G196 [Periódico revisado por pares]

United States

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Título:
CGRP upregulation in dorsal root ganglia and ileal mucosa during Clostridium difficile toxin A-induced enteritis
Autor: Keates, A C ; Castagliuolo, I ; Qiu, B ; Nikulasson, S ; Sengupta, A ; Pothoulakis, C
Assuntos: Animals ; Bacterial Toxins ; Calcitonin Gene-Related Peptide - biosynthesis ; Calcitonin Gene-Related Peptide - pharmacology ; Clostridium difficile ; Enteritis - chemically induced ; Enteritis - physiopathology ; Enteritis - prevention & control ; Enterotoxins - antagonists & inhibitors ; Enterotoxins - toxicity ; Ganglia, Spinal - drug effects ; Ganglia, Spinal - pathology ; Ganglia, Spinal - physiopathology ; Ileum ; Inflammation ; Intestinal Mucosa - drug effects ; Intestinal Mucosa - pathology ; Intestinal Mucosa - physiopathology ; Male ; Peptide Fragments - pharmacology ; Rats ; Rats, Wistar
É parte de: The American journal of physiology, 1998-01, Vol.274 (1), p.G196
Descrição: We have previously reported that pretreatment of rats with capsaicin (an agent that ablates sensory neurons) or CP-96345 (a substance P receptor antagonist) dramatically inhibits fluid secretion and intestinal inflammation in ileal loops exposed to Clostridium difficile toxin A. The aim of this study was to determine whether calcitonin gene-related peptide (CGRP), a neuropeptide also found in sensory afferent neurons, participates in the enterotoxic effects of toxin A. Administration of toxin A was also found to increase CGRP content in dorsal root ganglia and ileal mucosa 60 min after toxin exposure. Furthermore, immunohistochemical studies demonstrated increased neuronal staining for CGRP 2 h after toxin A treatment. Pretreatment of rats with CGRP-(8-37), a specific CGRP antagonist, before instillation of toxin A into ileal loops significantly inhibited toxin-mediated fluid secretion (by 48%), mannitol permeability (by 83%), and histological damage. We conclude that CGRP, like substance P, contributes to the secretory and inflammatory effects of toxin A via increased production of this peptide from intestinal nerves, including primary sensory afferent neurons.
Editor: United States
Idioma: Inglês

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CGRP upregulation in dorsal root ganglia and ileal mucosa during Clostridium difficile toxin A-induced enteritis

Keates, A C ; Castagliuolo, I ; Qiu, B ; Nikulasson, S ; Sengupta, A ; Pothoulakis, C

United States

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