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Changes in the molecular sieve of glomerular basement membrane in rats with aminonucleoside nephrosis

Takaya, Y ; Ota, Z ; Makino, H ; Kida, K ; Miyoshi, A ; Hiramatsu, M ; Takahashi, K ; Ofuji, T

Acta medica Okayama, 1980-02, Vol.34 (1), p.67 [Periódico revisado por pares]

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Título:
Changes in the molecular sieve of glomerular basement membrane in rats with aminonucleoside nephrosis
Autor: Takaya, Y ; Ota, Z ; Makino, H ; Kida, K ; Miyoshi, A ; Hiramatsu, M ; Takahashi, K ; Ofuji, T
Assuntos: Animals ; Basement Membrane - ultrastructure ; Kidney Glomerulus - ultrastructure ; Male ; Nephrotic Syndrome - chemically induced ; Nephrotic Syndrome - pathology ; Puromycin Aminonucleoside ; Rats
É parte de: Acta medica Okayama, 1980-02, Vol.34 (1), p.67
Descrição: Isolated and purified glomerular basement membranes (GBM) of normal and aminonucleoside (PAN) nephrosis rats were observed by electron microscopy after negative staining. Although GBM of normal rats appeared as a molecular sieve with uniform pores, GBM of nephrotic rats showed enlargement and elongation of the pores. For an average of fifty pores, the long dimension was 40.4+/-10.7 A and the short dimension 13.8+/-3.6 A in nephrosis whereas the long dimension was 12.3+/-2.5 A and the short dimension 8.4+/-1.0 A in normal rats. Changes in the pores in GBM were thought to result in increased permeability of serum protein and hence proteinuria.
Editor: Japan
Idioma: Inglês

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