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Association of cystathionine β-synthase gene polymorphisms with essential hypertension in ethnic Uyghurs and Hans from Xinjiang

Shi, Qingping ; Zhang, Ying ; Wang, Hong ; Ouyang, Juyan ; Chen, Fang ; Xu, Meng

Zhonghua yi xue yi chuan xue za zhi, 2015-02, Vol.32 (1), p.94

China

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  • Título:
    Association of cystathionine β-synthase gene polymorphisms with essential hypertension in ethnic Uyghurs and Hans from Xinjiang
  • Autor: Shi, Qingping ; Zhang, Ying ; Wang, Hong ; Ouyang, Juyan ; Chen, Fang ; Xu, Meng
  • Assuntos: Adult ; Aged ; China - ethnology ; Cystathionine beta-Synthase - genetics ; Essential Hypertension ; Female ; Gene-Environment Interaction ; Homocysteine - blood ; Humans ; Hypertension - genetics ; Logistic Models ; Male ; Middle Aged ; Polymorphism, Genetic
  • É parte de: Zhonghua yi xue yi chuan xue za zhi, 2015-02, Vol.32 (1), p.94
  • Descrição: To investigate the cystathione beta synthase (CBS) gene T833C, G919A, 844ins68 polymorphisms and plasma homocysteine (Hcy) levels in ethnic Uyghur and Han patients with essential hypertension (EH) in Xinjiang. Four hundred twenty nine cases including 211 Uyghur and 218 Han EH patients were recruited, whilst 410 healthy individuals including 210 Uyghurs and 200 Hans were used as the controls. Amplification refractory mutation system (ARMS) was adopted to analyze the CBS gene polymorphisms including T833C, G919A and 844ins68. Enzymoimmunoassay was applied to determine the plasma level of Hcy. Chemiluminescence was applied to determine the plasma folic acid and vitamin B12. Compared with the controls, the plasma Hcy level was significantly higher in the EH group in both ethnic Uyghurs and Hans (P < 0.05). Plasma levels of Hcy in T833C, G919A genotypes (for both heterozygotes and homozygotes) were statistically higher than wild types (P < 0.05). A significant difference was detected in G919A polymorphism between
  • Editor: China
  • Idioma: Chinês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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