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Association between adiponectin rs2241766, rs1501299 polymorphisms and the risk of colorectal cancer
Li, Xiaoling ; Liu, Wenhui ; Feng, Fei ; Hu, Xiaoqin ; Yuan, Ping ; Yan, Jin ; Yang, Yanfang
Zhōnghuá liúxíngbìng zázhì, 2014-02, Vol.35 (2), p.195
China
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Título:
Association between adiponectin rs2241766, rs1501299 polymorphisms and the risk of colorectal cancer
Autor:
Li, Xiaoling
;
Liu, Wenhui
;
Feng, Fei
;
Hu, Xiaoqin
;
Yuan, Ping
;
Yan, Jin
;
Yang, Yanfang
Assuntos:
Adiponectin - genetics
;
Adult
;
Aged
;
Case-Control Studies
;
Colorectal Neoplasms - epidemiology
;
Colorectal Neoplasms - genetics
;
Female
;
Gene-Environment Interaction
;
Genotype
;
Humans
;
Male
;
Middle Aged
;
Polymorphism, Single Nucleotide
;
Risk Factors
É parte de:
Zhōnghuá liúxíngbìng zázhì, 2014-02, Vol.35 (2), p.195
Descrição:
To explore the association between adiponectin rs2241766, rs1501299 polymorphisms and gene-environment interaction and the risk of colorectal cancer(CRC). Four hundred CRC patients confirmed by histopathology and 400 healthy controls were recruited in this study. Cases and controls were matched on age and gender. A well-designed questionnaire was used to collect the information of demography, lifestyle and dietary habit on the 400 case-control pairs. Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)was applied to detect the adiponectin rs2241766 and rs1501299 genotypes. Data from conditional logistic regression analysis showed that those carrying TG+GG genotype on rs2241766 having an increased risk compared to those that carrying TT genotype(OR = 1.354, 95%CI:1.004-1.827), and those that carrying GT+TT genotype on rs1501299 having an decreased risk when compared to those that carrying GG genotype(OR = 0.680, 95% CI:0.501-0.923), after adjusted by factors as CRC family history,BMI, s
Editor:
China
Idioma:
Chinês
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