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The expression of substance P in airway mucosa of guinea pigs with repetitive esophageal stimulation by hydrochloric acid

Li, Qin-zi ; Kong, Ling-fei ; Zhang, Shu-na ; Zhong, Zhao-shuang ; Zhang, Bao-hui ; Liu, Xiao-feng

Zhonghua jiehe he huxi zazhi, 2009-06, Vol.32 (6), p.426 [Periódico revisado por pares]

China

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  • Título:
    The expression of substance P in airway mucosa of guinea pigs with repetitive esophageal stimulation by hydrochloric acid
  • Autor: Li, Qin-zi ; Kong, Ling-fei ; Zhang, Shu-na ; Zhong, Zhao-shuang ; Zhang, Bao-hui ; Liu, Xiao-feng
  • Assuntos: Animals ; Esophagus ; Gastroesophageal Reflux - metabolism ; Guinea Pigs ; Hydrochloric Acid ; Inflammation ; Male ; Respiratory Mucosa - metabolism ; Substance P - biosynthesis
  • É parte de: Zhonghua jiehe he huxi zazhi, 2009-06, Vol.32 (6), p.426
  • Descrição: To observe the expression of substance P (SP) in the airway mucosa of guinea pigs with repetitive esophageal stimulation by hydrochloric acid (HCL). Twenty adult guinea pigs were randomly divided into 2 groups (n = 10 each): (1) The HCL model group: On the day of experimentation, guinea pigs were maintained under ketamine anesthesia. A 5F catheter was inserted orally into the lumen of the middle and lower esophagus. The esophagus of each animal was perfused with HCl-P for 20 min/d for 14 d. (2) The PBS control group: The esophagus of each animal was perfused with PBS instead. The bronchial responsiveness to Ach given intravenously with increasing doses (3.125, 6.25, 12.5, 25, 50, 100 microg/kg) was measured after the last perfusion. The left lung was isolated for pathological examination. Lung sections were stained with hematoxylin and eosin, and other sections were prepared for immunohistochemistry using monoclonal antibodies against SP. In response to increasing doses of ACh, all guinea pigs showed dose-dep
  • Editor: China
  • Idioma: Chinês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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