Idioma:

Association of polymorphisms of human leucocyte antigen -DRB1 and -DQA1 allele with outcomes of hepatitis B virus infection in Han population of north China

Lu, Liang-ping ; Liu, Ying ; Li, Xing-wang ; Sun, Guo-chang ; Zhu, Xi-lin ; Wu, Yun-zhong ; Hu, Quan-you ; Li, Hui

Zhōngguó yīxué kēxuéyuàn xuébào, 2006-04, Vol.28 (2), p.134 [Periódico revisado por pares]

China

Sem texto completo

Citações Citado por

Enviar para

Título:
Association of polymorphisms of human leucocyte antigen -DRB1 and -DQA1 allele with outcomes of hepatitis B virus infection in Han population of north China
Autor: Lu, Liang-ping ; Liu, Ying ; Li, Xing-wang ; Sun, Guo-chang ; Zhu, Xi-lin ; Wu, Yun-zhong ; Hu, Quan-you ; Li, Hui
Assuntos: Adolescent ; Adult ; Alcohol Drinking ; Asian Continental Ancestry Group - genetics ; Case-Control Studies ; Environment ; Female ; Gene Frequency ; Genetic Predisposition to Disease - genetics ; Hepatitis B - ethnology ; Hepatitis B - genetics ; HLA-DQ alpha-Chains ; HLA-DQ Antigens - genetics ; HLA-DR Antigens - genetics ; HLA-DRB1 Chains ; Humans ; Male ; Middle Aged ; Polymorphism, Genetic ; Risk Factors
É parte de: Zhōngguó yīxué kēxuéyuàn xuébào, 2006-04, Vol.28 (2), p.134
Descrição: To assess the association of polymorphisms of human leucocyte antigen (HLA) -DRB1 and -DQA1 region allele with outcomes of hepatitis B virus (HBV) infection in Han population of north China. A total of 207 chronic hepatitis B (HB) patients, 212 chronic asymptomatic HBV carriers (HBV carrier), and 148 self-limited HBV infection were recruited to examine the association between gene polymorphisms and outcomes of HBV infection. Polymerase chain reaction-sequence specific primers (PCR-SSP) technique was used to genotype HLA-DRB1 and HLA-DQA1 loci. The frequency of HLA-DQA1 * 0301 in chronic HB patients (14.81%) was significantly lower than those in HBV carriers (25.24%) and self-limited HBV infection subjects (25.00%) (Pc = 0.002; Pc = 0.007). The frequency of HLA-DQA1 * 0102 in self-limited HBV infection subjects (8.78%) was significantly higher than those in chronic HB patients (2.18%) and HBV carriers (1.89%) (Pc = 0.000; P = 0.000). In addition, the frequency of HLA-DQA1 * 0302 in self-limited HBV infection s
Editor: China
Idioma: Chinês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Association of polymorphisms of human leucocyte antigen -DRB1 and -DQA1 allele with outcomes of hepatitis B virus infection in Han population of north China

Lu, Liang-ping ; Liu, Ying ; Li, Xing-wang ; Sun, Guo-chang ; Zhu, Xi-lin ; Wu, Yun-zhong ; Hu, Quan-you ; Li, Hui

China

Buscando em bases de dados remotas. Favor aguardar.