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Muscle fatty acid oxidative capacity is a determinant of whole body fat oxidation in elderly people

Morio, Beatrice ; Hocquette, Jean-Francois ; Montaurier, Christophe ; Boirie, Yves ; Bouteloup-Demange, Corinne ; McCormack, Caroline ; Fellmann, Nicole ; Beaufrere, Bernard ; Ritz, Patrick

American journal of physiology: endocrinology and metabolism, 2001-01, Vol.280 (1), p.E143-E149 [Periódico revisado por pares]

United States: American Physiological Society

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  • Título:
    Muscle fatty acid oxidative capacity is a determinant of whole body fat oxidation in elderly people
  • Autor: Morio, Beatrice ; Hocquette, Jean-Francois ; Montaurier, Christophe ; Boirie, Yves ; Bouteloup-Demange, Corinne ; McCormack, Caroline ; Fellmann, Nicole ; Beaufrere, Bernard ; Ritz, Patrick
  • Assuntos: Aged ; Aging - metabolism ; Body Composition ; Calorimetry, Indirect ; Electron Transport Complex IV - metabolism ; Endocrinology and metabolism ; Exercise - physiology ; Fatty Acids - metabolism ; Female ; Human health and pathology ; Humans ; Life Sciences ; Life Style ; Male ; Middle Aged ; Muscle, Skeletal - enzymology ; Oxidation-Reduction ; Palmitates - metabolism ; Physical Endurance - physiology
  • É parte de: American journal of physiology: endocrinology and metabolism, 2001-01, Vol.280 (1), p.E143-E149
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: 1  Laboratoire de Nutrition Humaine, 2  Laboratoire de Physiologie et Biologie du Sport, Université d'Auvergne, Centre de Recherche en Nutrition Humaine d'Auvergne, 63009 Clermont-Ferrand; and 3  Institut National de la Recherche Agronomique, Unité de Recherches sur les Herbivores, 63122 Saint-Genès-Champanelle, France In sedentary elderly people, a reduced muscle fatty acid oxidative capacity (MFOC) may explain a decrease in whole body fat oxidation. Eleven sedentary and seven regularly exercising subjects (65.6 ± 4.5 yr) were characterized for their aerobic fitness [maximal O 2 uptake ( O 2 max )/kg fat free mass (FFM)] and their habitual daily physical activity level [free-living daily energy expenditure divided by sleeping metabolic rate (DEE FLC /SMR)]. MFOC was determined by incubating homogenates of vastus lateralis muscle with [1- 14 C]palmitate. Whole body fat oxidation was measured by indirect calorimetry over 24 h. MFOC was 40.4 ± 14.7 and 44.3 ± 16.3 nmol palmitate · g wet tissue 1 · min 1 in the sedentary and regularly exercising individuals, respectively ( P = nonsignificant). MFOC was positively correlated with DEE FLC /SMR ( r  = 0.58,  P < 0.05) but not with O 2 max /kg FFM ( r  =   0.35,  P = nonsignificant). MFOC was the main determinant of fat oxidation during all time periods including physical activity. Indeed, MFOC explained 19.7 and 30.5% of the variance in fat oxidation during walking and during the alert period, respectively ( P <   0.05). Furthermore, MFOC explained 23.0% of the variance in fat oxidation over 24 h ( P < 0.05). It was concluded that, in elderly people, MFOC may be influenced more by overall daily physical activity than by regular exercising. MFOC is a major determinant of whole body fat oxidation during physical activities and, consequently, over 24   h. habitual physical activity; endurance training; indirect calorimetry; vastus lateralis muscle
  • Editor: United States: American Physiological Society
  • Idioma: Inglês
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