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Hepatoprotective potential of aqueous extract of Butea monosperma against CCl(4) induced damage in rats

Sharma, Neetu ; Shukla, Sangeeta

Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie, 2011-11, Vol.63 (7-8), p.671-676 [Periódico revisado por pares]

Germany

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Título:
Hepatoprotective potential of aqueous extract of Butea monosperma against CCl(4) induced damage in rats
Autor: Sharma, Neetu ; Shukla, Sangeeta
Assuntos: Adenosine Triphosphatases - metabolism ; Animals ; Blood Chemical Analysis ; Butea - chemistry ; Carbon Tetrachloride - toxicity ; Carbon Tetrachloride Poisoning - prevention & control ; Chemical and Drug Induced Liver Injury - etiology ; Chemical and Drug Induced Liver Injury - pathology ; Chemical and Drug Induced Liver Injury - prevention & control ; Drug Therapy, Combination ; Female ; Flowers - chemistry ; Glucose-6-Phosphatase - metabolism ; Hexobarbital - pharmacology ; Liver - drug effects ; Liver - enzymology ; Liver - pathology ; Mice ; Plant Extracts - pharmacology ; Protective Agents - pharmacology ; Rats ; Rats, Sprague-Dawley ; Sleep - drug effects ; Sulfobromophthalein
É parte de: Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie, 2011-11, Vol.63 (7-8), p.671-676
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Aqueous extract of flowers of Butea monosperma (Fabaceae) was evaluated at different dose levels (200, 400, 800 mg/kg, p.o.) for its protective efficacy against CCl(4) (1.5 ml/kg i.p.) induced acute liver injury to validate its use in traditional medicines. The CCl(4) administration altered various biochemical parameters, including serum transaminases, protein, albumin, hepatic lipid peroxidation, reduced glutathione and total protein levels, which were restored towards control by therapy of B. monosperma Adenosine triphosphatase and glucose-6-phosphatase activity in the liver were decreased significantly in CCl(4) treated animals. Therapy of B. monosperma showed its protective effect on biochemical and histopathological alterations at all the three doses in dose dependent manner. B. monosperma extract possess modulatory effect on drug metabolizing enzymes as it significantly decreased the hexobarbitone induced sleep time and increased excretory capacity of liver which was measured by BSP retention. Histological studies also supported the biochemical finding and maximum improvement in the histoarchitecture was seen at higher dose of BM extract.
Editor: Germany
Idioma: Inglês

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Hepatoprotective potential of aqueous extract of Butea monosperma against CCl(4) induced damage in rats

Sharma, Neetu ; Shukla, Sangeeta

Germany

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