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DNA Polymerase and Topoisomerase II Inhibitors from Psoralea corylifolia

Sun, Nan Jun ; Woo, Sung Ho ; Cassady, John M ; Snapka, Robert M

Journal of natural products (Washington, D.C.), 1998-03, Vol.61 (3), p.362-366 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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Título:
DNA Polymerase and Topoisomerase II Inhibitors from Psoralea corylifolia
Autor: Sun, Nan Jun ; Woo, Sung Ho ; Cassady, John M ; Snapka, Robert M
Assuntos: ACEITES ESENCIALES ; AGENTES ANTINEOPLASTICOS ; ANTINEOPLASTIC AGENTS ; BAKUCHICIN ; BAKUCHIOL ; Biological and medical sciences ; CHEMICAL COMPOSITION ; CHEMICAL STRUCTURE ; China ; COMPOSICION QUIMICA ; COMPOSITION CHIMIQUE ; CORYLIFOLIN ; DAIDZEIN ; ENZYME INHIBITORS ; Enzyme Inhibitors - isolation & purification ; Enzyme Inhibitors - pharmacology ; ESPECTROMETRIA ; ESSENTIAL OILS ; ESTRUCTURA QUIMICA ; FLAVONOIDE ; FLAVONOIDES ; FLAVONOIDS ; FRUITS ; FRUTAS ; General pharmacology ; HUILE ESSENTIELLE ; HUNAN ; INHIBIDORES DE ENZIMAS ; INHIBITEUR D'ENZYME ; ISOMERASAS ; ISOMERASE ; ISOMERASES ; Magnetic Resonance Spectroscopy ; Medical sciences ; MEDICAMENT CYTOSTATIQUE ; NEOBAVAISOFLAVONE ; Nucleic Acid Synthesis Inhibitors ; PHARMACEUTICAL PRODUCTS ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phenols - isolation & purification ; Phenols - pharmacology ; Plants, Medicinal - chemistry ; PSORALEA CORYLIFOLIA ; RESVERATROL ; Simian virus 40 - drug effects ; SPECTRAL ANALYSIS ; SPECTROMETRIE ; SPECTROMETRY ; STRUCTURE CHIMIQUE ; TERPENOIDE ; TERPENOIDOS ; TERPENOIDS ; Topoisomerase II Inhibitors ; TRANSFERASAS ; TRANSFERASE ; TRANSFERASES ; Virus Replication - drug effects
É parte de: Journal of natural products (Washington, D.C.), 1998-03, Vol.61 (3), p.362-366
Notas: 1997072272
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Descrição: An ethanol extract of Psoralea corylifolia caused strong DNA polymerase inhibition in a whole cell bioassay specific for inhibitors of DNA replication enzymes. Bioassay-directed purification of the active compounds led to the isolation of the new compound corylifolin (1) and the known compound bakuchiol (2) as DNA polymerase inhibitors. On the basis of the structures of 1 and 2, resveratrol (3) was tested and found to be active as a DNA polymerase inhibitor in this bioassay. Neobavaisoflavone (4) was isolated as a DNA polymerase inhibitor, daidzein (5) as a DNA polymerase and topoisomerase II inhibitor, and bakuchicin (6) as a topoisomerase II inhibitor.
Editor: Washington, DC: American Chemical Society
Idioma: Inglês

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DNA Polymerase and Topoisomerase II Inhibitors from Psoralea corylifolia

Sun, Nan Jun ; Woo, Sung Ho ; Cassady, John M ; Snapka, Robert M

Washington, DC: American Chemical Society

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