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Inflammatory response in acute traumatic brain injury: a double-edged sword

Morganti-Kossmann, Maria Cristina ; Rancan, Mario ; Stahel, Philip F ; Kossmann, Thomas

Current opinion in critical care, 2002-04, Vol.8 (2), p.101-105

United States

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Título:
Inflammatory response in acute traumatic brain injury: a double-edged sword
Autor: Morganti-Kossmann, Maria Cristina ; Rancan, Mario ; Stahel, Philip F ; Kossmann, Thomas
Assuntos: Animals ; Brain Injuries - physiopathology ; Cytokines - physiology ; Encephalitis - complications ; Encephalitis - physiopathology ; Humans ; Intercellular Adhesion Molecule-1 - physiology ; Interleukin-10 - physiology ; Interleukin-6 - physiology ; Leukocytes - physiology ; Mice ; Transforming Growth Factor beta - physiology ; Tumor Necrosis Factor-alpha - physiology
É parte de: Current opinion in critical care, 2002-04, Vol.8 (2), p.101-105
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Inflammation is an important part of the pathophysiology of traumatic brain injury. Although the central nervous system differs from the other organs because of the almost complete isolation from the blood stream mediated by the blood-brain barrier, the main steps characterizing the immune activation within the brain follow a scenario similar to that in other organs. The key players in these processes are the numerous immune mediators released within minutes of the primary injury. They guide a sequence of events including expression of adhesion molecules, cellular infiltration, and additional secretion of inflammatory molecules and growth factors, resulting in either regeneration or cell death. The question is this: to what extent is inflammation beneficial for the injured brain tissue, and how does it contribute to secondary brain damage and progressive neuronal loss? This review briefly reports recent evidence supporting the dual, the beneficial, or the deleterious role of neuroinflammation after traumatic brain injury.
Editor: United States
Idioma: Inglês

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Inflammatory response in acute traumatic brain injury: a double-edged sword

Morganti-Kossmann, Maria Cristina ; Rancan, Mario ; Stahel, Philip F ; Kossmann, Thomas

United States

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