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Tunicamycin inhibits the initiation of DNA synthesis stimulated by prostaglandin F2α in Swiss mouse 3T3 cells

Estevez, Alvaro G. ; Calamante, Gabriela ; Goin, Mercedes ; de Asua, Luis Jimenez

FEBS letters, 1991-09, Vol.290 (1-2), p.239-242 [Periódico revisado por pares]

Amsterdam: Elsevier

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Título:
Tunicamycin inhibits the initiation of DNA synthesis stimulated by prostaglandin F2α in Swiss mouse 3T3 cells
Autor: Estevez, Alvaro G. ; Calamante, Gabriela ; Goin, Mercedes ; de Asua, Luis Jimenez
Assuntos: 3T3 Cells ; Animals ; Biological and medical sciences ; Cell Division - drug effects ; Cell physiology ; Dinoprost - antagonists & inhibitors ; DNA - biosynthesis ; DNA synthesis ; Fundamental and applied biological sciences. Psychology ; Glucosamine - metabolism ; Glycoproteins - physiology ; In Vitro Techniques ; Insulin - pharmacology ; Lag phase ; Mannose - metabolism ; Mice ; Molecular and cellular biology ; PGF2α ; Prostaglandin F2α ; Responses to growth factors, tumor promotors, other factors ; Swiss 3T3 cell ; Time Factors ; Tunicamycin ; Tunicamycin - pharmacology
É parte de: FEBS letters, 1991-09, Vol.290 (1-2), p.239-242
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Tunicamycin, an inhibitor of the asparagine‐linked protein N‐glycosylation, blocks the initiation of DNA synthesis in Swiss 3T3 cells stimulated by prostaglandin F2α alone or with insulin. This effect is exerted only when tunicamycin is added from 0 to 8 h after stimulation and it decreases the rate of entry into S phase. Blocking of labeled sugar incorporation to proteins occurs regardless of the time of PGF2α stimulation. In contrast tunicamicin does not inhibit protein synthesis. These results suggest that N‐glycoprotein synthesis early during the prereplicative phase is an important event controlling the mitogenic action of PGF2α
Editor: Amsterdam: Elsevier
Idioma: Inglês

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Tunicamycin inhibits the initiation of DNA synthesis stimulated by prostaglandin F2α in Swiss mouse 3T3 cells

Estevez, Alvaro G. ; Calamante, Gabriela ; Goin, Mercedes ; de Asua, Luis Jimenez

Amsterdam: Elsevier

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