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Fluoxetine attenuates the effects of pentylenetetrazol on rat freezing behavior and c-Fos expression in the dorsomedial periaqueductal gray

Zienowicz, Małgorzata ; Wisłowska-Stanek, Aleksandra ; Lehner, Małgorzata ; Taracha, Ewa ; Skórzewska, Anna ; Bidziński, Andrzej ; Turzyńska, Danuta ; Sobolewska, Alicja ; Walkowiak, Jerzy ; Maciejak, Piotr ; Szyndler, Janusz ; Płaźnik, Adam

Neuroscience letters, 2007-03, Vol.414 (3), p.252-256 [Periódico revisado por pares]

Shannon: Elsevier Ireland Ltd

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Título:
Fluoxetine attenuates the effects of pentylenetetrazol on rat freezing behavior and c-Fos expression in the dorsomedial periaqueductal gray
Autor: Zienowicz, Małgorzata ; Wisłowska-Stanek, Aleksandra ; Lehner, Małgorzata ; Taracha, Ewa ; Skórzewska, Anna ; Bidziński, Andrzej ; Turzyńska, Danuta ; Sobolewska, Alicja ; Walkowiak, Jerzy ; Maciejak, Piotr ; Szyndler, Janusz ; Płaźnik, Adam
Assuntos: Animals ; Avoidance Learning - drug effects ; Avoidance Learning - physiology ; Behavior, Animal - drug effects ; Behavior, Animal - physiology ; Biological and medical sciences ; Biomarkers - metabolism ; c-Fos ; Conditioning (Psychology) - drug effects ; Conditioning (Psychology) - physiology ; Contextual fear conditioning ; Fear - drug effects ; Fear - physiology ; Fluoxetine (Flx) ; Fluoxetine - pharmacology ; Fluoxetine - therapeutic use ; Freezing reaction ; Freezing Reaction, Cataleptic - drug effects ; Freezing Reaction, Cataleptic - physiology ; Fundamental and applied biological sciences. Psychology ; GABA Antagonists - pharmacology ; Limbic System - drug effects ; Limbic System - metabolism ; Limbic System - physiopathology ; Male ; Motor Activity - drug effects ; Motor Activity - physiology ; Neural Pathways - drug effects ; Neural Pathways - metabolism ; Neural Pathways - physiopathology ; Pentylenetetrazol (PTZ) ; Pentylenetetrazole - antagonists & inhibitors ; Pentylenetetrazole - pharmacology ; Periaqueductal gray (PAG) ; Periaqueductal Gray - drug effects ; Periaqueductal Gray - metabolism ; Periaqueductal Gray - physiopathology ; Proto-Oncogene Proteins c-fos - drug effects ; Proto-Oncogene Proteins c-fos - metabolism ; Rats ; Rats, Wistar ; Serotonin - metabolism ; Serotonin Uptake Inhibitors - pharmacology ; Serotonin Uptake Inhibitors - therapeutic use ; Synaptic Transmission - drug effects ; Synaptic Transmission - physiology ; Treatment Outcome ; Vertebrates: nervous system and sense organs
É parte de: Neuroscience letters, 2007-03, Vol.414 (3), p.252-256
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Descrição: The aim of the study was to investigate the role of the periaqueductal gray (PAG) in anxiolytic-like actions of fluoxetine in animals treated with an anxiogenic drug, pentylenetetrazol (PTZ), and subjected to fear conditioning procedure. The data showed that PTZ given at the dose of 30 mg/kg 15 min before a retention trial significantly decreased freezing reaction ( p < 0.01), and potently enhanced rat locomotor activity ( p < 0.01), in comparison to the control group. These effects were reversed by prior (60 min) administration of fluoxetine (20 mg/kg). Simultaneously, PTZ significantly increased c-Fos expression in the dorsomedial periaqueductal gray (DMPAG), examined 2 h after the retention trial, in comparison to the control group ( p < 0.01). Fluoxetine (20 mg/kg) administered 60 min before PTZ reversed this effect. PTZ given at the same dose and time interval in the open field test did not affect rat locomotor behavior. Importantly, fluoxetine pretreatment did not change PTZ concentration in brain tissue. Our experiment based on PTZ-enhanced aversive conditioning revealed that acutely administered fluoxetine antagonized PTZ-induced panic-like behavior, and this phenomenon was accompanied by inhibition of activity of DMPAG.
Editor: Shannon: Elsevier Ireland Ltd
Idioma: Inglês

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Fluoxetine attenuates the effects of pentylenetetrazol on rat freezing behavior and c-Fos expression in the dorsomedial periaqueductal gray

Zienowicz, Małgorzata ; Wisłowska-Stanek, Aleksandra ; Lehner, Małgorzata ; Taracha, Ewa ; Skórzewska, Anna ; Bidziński, Andrzej ; Turzyńska, Danuta ; Sobolewska, Alicja ; Walkowiak, Jerzy ; Maciejak, Piotr ; Szyndler, Janusz ; Płaźnik, Adam

Shannon: Elsevier Ireland Ltd

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