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Cannabinoid receptors in microglia of the central nervous system: immune functional relevance

Cabral, G. A. ; Marciano‐Cabral, F.

Journal of leukocyte biology, 2005-12, Vol.78 (6), p.1192-1197 [Periódico revisado por pares]

United States: Society for Leukocyte Biology

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Título:
Cannabinoid receptors in microglia of the central nervous system: immune functional relevance
Autor: Cabral, G. A. ; Marciano‐Cabral, F.
Assuntos: Animals ; brain immune modulation ; Cannabinoids - metabolism ; Cannabinoids - pharmacology ; Central Nervous System - cytology ; Central Nervous System - immunology ; Central Nervous System - metabolism ; cytokines ; Encephalitis - drug therapy ; Encephalitis - immunology ; Encephalitis - prevention & control ; Gliosis - drug therapy ; Gliosis - immunology ; Gliosis - prevention & control ; Humans ; Immune System - immunology ; marijuana ; Microglia - immunology ; Microglia - metabolism ; nitric oxide ; Receptor, Cannabinoid, CB1 - genetics ; Receptor, Cannabinoid, CB1 - immunology ; Receptor, Cannabinoid, CB2 - genetics ; Receptor, Cannabinoid, CB2 - immunology ; Receptors, Cannabinoid - immunology
É parte de: Journal of leukocyte biology, 2005-12, Vol.78 (6), p.1192-1197
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Descrição: Microglia, resident macrophages of the brain, function as immune effector and accessory cells. Paradoxically, they not only play a role in host defense and tissue repair but also have been implicated in a variety of neuropathological processes. Microglia, in addition to exhibiting phenotypic markers for macrophages, express CB1 and CB2 cannabinoid receptors. Recent studies suggest the existence of a third, yet‐to‐be cloned, non‐CB1, non‐CB2 cannabinoid receptor. These receptors appear to be functionally relevant within defined windows of microglial activation state and have been implicated as linked to cannabinoid modulation of chemokine and cytokine expression. The recognition that microglia express cannabinoid receptors and that their activation results in modulation of select cellular activities suggests that they may be amenable to therapeutic manipulation for ablating untoward inflammatory responses in the central nervous system.
Editor: United States: Society for Leukocyte Biology
Idioma: Inglês

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Cannabinoid receptors in microglia of the central nervous system: immune functional relevance

Cabral, G. A. ; Marciano‐Cabral, F.

United States: Society for Leukocyte Biology

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