Idioma:

G‐banding and molecular cytogenetic analyses of marginal zone lymphoma

Aamot, Hege Vangstein ; Micci, Francesca ; Holte, Harald ; Delabie, Jan ; Heim, Sverre

British journal of haematology, 2005-09, Vol.130 (6), p.890-901 [Periódico revisado por pares]

Oxford, UK: Blackwell Science Ltd

Texto completo disponível

Citações Citado por

Enviar para

Título:
G‐banding and molecular cytogenetic analyses of marginal zone lymphoma
Autor: Aamot, Hege Vangstein ; Micci, Francesca ; Holte, Harald ; Delabie, Jan ; Heim, Sverre
Assuntos: Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; chromosome 3 ; Chromosome Aberrations ; Chromosome Banding - methods ; Chromosomes, Human, Pair 3 - genetics ; Female ; Hematologic and hematopoietic diseases ; Humans ; In Situ Hybridization, Fluorescence - methods ; Karyotyping ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphoma, B-Cell, Marginal Zone - genetics ; marginal zone lymphoma ; Medical sciences ; Middle Aged ; molecular cytogenetics ; Nucleic Acid Hybridization - methods ; Prognosis ; RHOH/TTF ; Survival Analysis ; Translocation, Genetic
É parte de: British journal of haematology, 2005-09, Vol.130 (6), p.890-901
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Summary We analysed the acquired chromosomal aberrations of 22 marginal zone lymphoma (MZL) patients by various genome‐wide cytogenetic techniques, such as G‐banding, multicolour fluorescence in situ hybridisation (M‐FISH), cross‐species colour banding (RxFISH), and comparative genomic hybridisation (CGH), as well as FISH with locus‐specific probes. Patients with an abnormal chromosome 3 (n = 11), the most frequently rearranged chromosome, showed a shorter median survival than patients with a normal chromosome 3 (n = 11, 74 months vs. 219 months, P < 0·03). Four of five patients with nodal MZL had chromosome 3 abnormalities and patients with nodal MZL had a shorter median survival than patients in the other morphological subgroups of MZL (P < 0·003). CGH analysis showed only gains of chromosome material, namely of chromosome regions 3p12–25, 3q12–21, 3q23–28, 12q13–15, 12q22–24, 19p13 and 19q13 in two to four cases each (20–40%). In two MZL, the novel unbalanced translocation der(13)t(3;13)(q24;p11) was detected as the sole karyotypic rearrangement, indicating that gain of 3q24‐qter could be an important event in the pathogenesis of these lymphomas. Another two cases showed, in addition to other abnormalities, a t(4;14)(p13;q32). Both these lymphomas had involvement of the IGH gene at 14q32, and one of them also of the RHOH/TTF gene at 4p13, which encodes a new member of the RHO protein subfamily.
Editor: Oxford, UK: Blackwell Science Ltd
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

G‐banding and molecular cytogenetic analyses of marginal zone lymphoma

Aamot, Hege Vangstein ; Micci, Francesca ; Holte, Harald ; Delabie, Jan ; Heim, Sverre

Oxford, UK: Blackwell Science Ltd

Buscando em bases de dados remotas. Favor aguardar.