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Does crocin create new hope for the treatment of oral problems? A focus on periodontitis

Rekabi, Atefe ; Ram, Arman ; Nazari, Ahmad ; Arefnezhad, Reza ; Rezaei-Tazangi, Fatemeh

Molecular biology reports, 2024-12, Vol.51 (1), p.224-224, Article 224 [Periódico revisado por pares]

Dordrecht: Springer Netherlands

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Título:
Does crocin create new hope for the treatment of oral problems? A focus on periodontitis
Autor: Rekabi, Atefe ; Ram, Arman ; Nazari, Ahmad ; Arefnezhad, Reza ; Rezaei-Tazangi, Fatemeh
Assuntos: Alveolar bone ; Alzheimer's disease ; Animal Anatomy ; Animal Biochemistry ; Biomedical and Life Sciences ; Carotenoids - pharmacology ; Carotenoids - therapeutic use ; Chronic Disease ; Collagen ; Gum disease ; Histology ; Humans ; Immune system ; Inflammation ; Kidney diseases ; Life Sciences ; Metabolic syndrome ; Mini Review ; Morphology ; Neurodegenerative diseases ; Oral diseases ; Osteoclasts ; Osteoporosis ; Periodontal Ligament ; Periodontitis ; Periodontitis - drug therapy ; Periodontitis - microbiology ; Public health ; Respiratory diseases
É parte de: Molecular biology reports, 2024-12, Vol.51 (1), p.224-224, Article 224
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: According to the World Health Organization (WHO) reports, oral health has an indispensable role in the maintenance of human public health. However, oral problems, especially periodontitis, are known as bad players in this issue. Periodontitis, as the most prevalent oral disease, is a type of chronic illness mediated by bacterial pathogens and immune system reactions, which is linked with the destruction of tooth-protecting tissues, such as alveolar bone and periodontal ligament. Periodontitis has a high prevalence (over 40% in the United States) and can be associated with other systemic ailments, for instance, arthritis, osteoporosis, metabolic syndrome, cancer, respiratory diseases, chronic kidney disease, and Alzheimer’s disease. The common treatments for periodontitis are classified into invasive (surgical) and noninvasive (antibiotic therapy, scaling, and root planning) methods; however, these therapies have not reflected enough effectiveness for related patients. New documents inform the beneficial effects of plant-based compounds in healing various disorders, like periodontitis. In conjunction with this subject, it has been revealed that crocin, as an active component of saffron, regulates the balance between osteoclasts and osteoblasts and has a stroking role in the accumulation of the most common collagen in teeth and bone (type 1 collagen). Besides, this carotenoid compound possesses anti-inflammatory and anti-oxidative effects, which can be associated with the therapeutic processes of crocin in this oral disease. Hence, this narrative review study was performed to reflect the reparative/regenerative aspects of crocin agonist periodontitis.
Editor: Dordrecht: Springer Netherlands
Idioma: Inglês

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Does crocin create new hope for the treatment of oral problems? A focus on periodontitis

Rekabi, Atefe ; Ram, Arman ; Nazari, Ahmad ; Arefnezhad, Reza ; Rezaei-Tazangi, Fatemeh

Dordrecht: Springer Netherlands

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