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Successful treatment of classic Kaposi sarcoma with Trichophyton rubrum–infected onychomycosis and tinea pedis utilizing combination of oral itraconazole and thalidomide

Chen, Jincong ; Zheng, Yaxuan ; Zhu, Changhua ; Lin, Lihang ; Su, Huichun

Journal of dermatology, 2024-05, Vol.51 (5), p.727-730 [Periódico revisado por pares]

England: Wiley Subscription Services, Inc

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Título:
Successful treatment of classic Kaposi sarcoma with Trichophyton rubrum–infected onychomycosis and tinea pedis utilizing combination of oral itraconazole and thalidomide
Autor: Chen, Jincong ; Zheng, Yaxuan ; Zhu, Changhua ; Lin, Lihang ; Su, Huichun
Assuntos: Administration, Oral ; Aged ; Antifungal agents ; Antifungal Agents - administration & dosage ; Antifungal Agents - therapeutic use ; antivascular effect ; Arthrodermataceae ; Drug Therapy, Combination - methods ; fungi ; Herpes viruses ; Humans ; Itraconazole ; Itraconazole - administration & dosage ; Itraconazole - therapeutic use ; Kaposi sarcoma ; Male ; Onychomycosis ; Onychomycosis - diagnosis ; Onychomycosis - drug therapy ; Onychomycosis - microbiology ; Sarcoma ; Sarcoma, Kaposi - complications ; Sarcoma, Kaposi - diagnosis ; Sarcoma, Kaposi - drug therapy ; Skin diseases ; Skin lesions ; Skin Neoplasms - complications ; Skin Neoplasms - diagnosis ; Skin Neoplasms - drug therapy ; Skin Neoplasms - microbiology ; Skin Neoplasms - pathology ; Thalidomide ; Thalidomide - administration & dosage ; Thalidomide - therapeutic use ; Tinea pedis ; Tinea Pedis - diagnosis ; Tinea Pedis - drug therapy ; Tinea Pedis - microbiology ; Treatment Outcome ; Trichophyton - isolation & purification ; Trichophyton rubrum
É parte de: Journal of dermatology, 2024-05, Vol.51 (5), p.727-730
Notas: Jincong Chen and Yaxuan Zheng contributed equally and should be regarded as co‐first authors.
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Descrição: Kaposi sarcoma (KS) is a vascular proliferative tumor caused by human herpesvirus 8. At present, the treatment of KS is difficult and refractory. Here, we report a 68‐year‐old man who was diagnosed with a classical KS with tinea pedis and onychomycosis, infected by Trichophyton rubrum, and treated with itraconazole and thalidomide after locational excision of several bigger nodules. The lesions were relieved during treatment, and recurred after discontinuation. Retreatment still achieved good effect and the therapy was tapered down after control. After the whole course of treatment, the skin lesions subsided significantly without obvious adverse reactions, which showed that itraconazole combined with thalidomide may be another effective and safe treatment for KS in some cases.
Editor: England: Wiley Subscription Services, Inc
Idioma: Inglês

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Successful treatment of classic Kaposi sarcoma with Trichophyton rubrum–infected onychomycosis and tinea pedis utilizing combination of oral itraconazole and thalidomide

Chen, Jincong ; Zheng, Yaxuan ; Zhu, Changhua ; Lin, Lihang ; Su, Huichun

England: Wiley Subscription Services, Inc

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