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Interleukin-24 is a novel diagnostic biomarker for the severity of acute kidney injury

Tabata, Tomotake ; Sugiyama, Noriyuki ; Otsuki, Yoshinori ; Kondo, Yoichi

Medical molecular morphology, 2020-06, Vol.53 (2), p.115-123 [Periódico revisado por pares]

Singapore: Springer Singapore

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Título:
Interleukin-24 is a novel diagnostic biomarker for the severity of acute kidney injury
Autor: Tabata, Tomotake ; Sugiyama, Noriyuki ; Otsuki, Yoshinori ; Kondo, Yoichi
Assuntos: Acute Kidney Injury - blood ; Acute Kidney Injury - diagnosis ; Acute Kidney Injury - pathology ; Acute Kidney Injury - urine ; Anatomy ; Animals ; Atrophy - blood ; Atrophy - diagnosis ; Atrophy - pathology ; Atrophy - urine ; Biomarkers ; Biomarkers - blood ; Biomarkers - metabolism ; Biomarkers - urine ; Cell Communication ; Cell interactions ; Cells, Cultured ; Creatinine ; Cytokines ; Cytokines - blood ; Cytokines - metabolism ; Cytokines - urine ; Disease Models, Animal ; Disease Progression ; Epithelial cells ; Epithelial Cells - pathology ; Gelatinase ; Humans ; Interleukin 24 ; Ischemia ; Kidney diseases ; Kidney Tubules - blood supply ; Kidney Tubules - cytology ; Kidney Tubules - pathology ; Kidneys ; Lipocalin ; Lipocalin-2 - blood ; Male ; Medicine ; Medicine & Public Health ; Mice ; Molecular Medicine ; Muscle, Smooth, Vascular - cytology ; Muscle, Smooth, Vascular - pathology ; Myocytes, Smooth Muscle - pathology ; Original Paper ; Pathology ; Primary Cell Culture ; Prognosis ; Reperfusion ; Reperfusion Injury - blood ; Reperfusion Injury - diagnosis ; Reperfusion Injury - pathology ; Reperfusion Injury - urine ; Severity of Illness Index ; Smooth muscle ; Therapeutic applications
É parte de: Medical molecular morphology, 2020-06, Vol.53 (2), p.115-123
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: There is a clinical need for sensitive acute kidney injury (AKI) biomarkers that enable early therapeutic interventions and prediction of disease prognosis. In this study, we monitored interleukin (IL)-24 expressed in kidneys with severe AKI that progresses to atrophic kidney in a mouse model of ischemia–reperfusion injury (IRI). Therefore, we evaluated IL-24 as a potential biomarker not only for early diagnosis of AKI, but also for predicting progression to chronic kidney disease (CKD). Serum IL-24 was detected earlier than the elevation of serum creatinine levels and urinary IL-24 was detected as early as neutrophil gelatinase associated lipocalin (NGAL) in severe AKI (60 min of IRI). In addition, serum and urine IL-24 levels tended to increase in relation to ischemia duration. In such kidneys, vascular smooth muscle cells expressed IL-24 in response to the injury in the renal tubular epithelial cell and its target was the renal tubular epithelial cell itself. IL-24 may play a pivotal role in the communication between tubular epithelial cells and vascular smooth muscle cells and, in conclusion, IL-24 can be used as a sensitive biomarker for AKI.
Editor: Singapore: Springer Singapore
Idioma: Inglês

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Interleukin-24 is a novel diagnostic biomarker for the severity of acute kidney injury

Tabata, Tomotake ; Sugiyama, Noriyuki ; Otsuki, Yoshinori ; Kondo, Yoichi

Singapore: Springer Singapore

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